Evidence map›Paper›PMID 36822205›Full record

ArticleImmunity2023

Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir.

Chaoqun Wang, Ben Hyams, Nancy C Allen, Kelly Cautivo, Kiara Monahan, Minqi Zhou, Madelene W Dahlgren, Carlos O Lizama, Michael Matthay, Paul Wolters and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
23.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 73 citations in OpenAlex.

  1. Review
  2. Preclinical models of COPD: a state of the art review.The European respiratory journal · 2026
    Review
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  6. AARS1-Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. TGFb signaling instructs a conserved fibrosis-associated cell state marked by LRRC15.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Observational
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  14. Review
  15. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Chaoqun WangDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Zhongshan Institute for Drug Discovery, Chinese Academy of Sciences, Zhongshan 528400, China.
Ben HyamsDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Cardiovascular Institute and Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Nancy C AllenDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Cardiovascular Institute and Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Kelly CautivoDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Bakar ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA.
Kiara MonahanDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Cardiovascular Institute and Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Minqi ZhouDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Cardiovascular Institute and Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Madelene W DahlgrenDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Bakar ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA.
Carlos O LizamaCardiovascular Institute and Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Michael MatthayDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Paul WoltersDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Ari B MolofskyDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Bakar ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: ari.molofsky@ucsf.edu.
Tien PengDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Cardiovascular Institute and Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Bakar ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: tien.peng@ucsf.edu.
University of California, San Francisco · US

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8M
Defining group 2 innate lymphoid cell lung nichesR01HL142701 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOLOFSKY, ARI B · 2019 to 2022
$2.5M
Mesenchymal modulation of epithelial metaplasia in lung fibrosisR01HL155622 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PENG, TIEN · 2021 to 2024
$2.3M
Maintenance of the alveolar niche in emphysemaR01HL142552 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PENG, TIEN · 2018 to 2021
$2.3M
NHLBI NIH HHS R01 HL142552NHLBI NIH HHS R01 HL142701NHLBI NIH HHS R01 HL155622NIDDK NIH HHS P30 DK063720
6 · The paper itself

Abstract

Aberrant tissue-immune interactions are the hallmark of diverse chronic lung diseases. Here, we sought to define these interactions in emphysema, a progressive disease characterized by infectious exacerbations and loss of alveolar epithelium. Single-cell analysis of human emphysema lungs revealed the expansion of tissue-resident lymphocytes (TRLs). Murine studies identified a stromal niche for TRLs that expresses Hhip, a disease-variant gene downregulated in emphysema. Stromal-specific deletion of Hhip induced the topographic expansion of TRLs in the lung that was mediated by a hyperactive hedgehog-IL-7 axis. 3D immune-stem cell organoids and animal models of viral exacerbations demonstrated that expanded TRLs suppressed alveolar stem cell growth through interferon gamma (IFNγ). Finally, we uncovered an IFNγ-sensitive subset of human alveolar stem cells that was preferentially lost in emphysema. Thus, we delineate a stromal-lymphocyte-epithelial stem cell axis in the lung that is modified by a disease-variant gene and confers host susceptibility to emphysema.

Indexed as

EmphysemaPulmonary Disease, Chronic ObstructivePulmonary EmphysemaAnimalsHumansLungLymphocytesMiceStem Cellsadventitiaalveolar stem cellCOPDemphysemafibroblasthedgehogHHIPinterferon gammarespiratory viral infectiontissue-resident lymphocytes

Identifiers

PMID36822205
PMCPMC10578134
OpenAlexW4321491194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.