Evidence map›Paper›PMID 36821889›Full record

ArticleEBioMedicine2023

Incorporating variant frequencies data into short-term forecasting for COVID-19 cases and deaths in the USA: a deep learning approach.

Hongru Du, Ensheng Dong, Hamada S Badr, Mary E Petrone, Nathan D Grubaugh, Lauren M Gardner

Open access · goldAbstract read
In one paragraph

Article in EBioMedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

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  3. Machine learning and probabilistic approaches for forecasting infectious disease transmission and cases.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hongru DuCenter for Systems Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA; Department of Civil and Systems Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Ensheng DongCenter for Systems Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA; Department of Civil and Systems Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Hamada S BadrCenter for Systems Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA; Department of Civil and Systems Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA; Department of Earth and Planetary Sciences, Johns Hopkins University, Baltimore, MD, 21218, USA.
Mary E PetroneDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA.
Nathan D GrubaughDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06510, USA; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, 06510, USA.
Lauren M GardnerCenter for Systems Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA; Department of Civil and Systems Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA. Electronic address: l.gardner@jhu.edu.
Johns Hopkins University · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

backgroundSince the US reported its first COVID-19 case on January 21, 2020, the science community has been applying various techniques to forecast incident cases and deaths. To date, providing an accurate and robust forecast at a high spatial resolution has proved challenging, even in the short term.

methodHere we present a novel multi-stage deep learning model to forecast the number of COVID-19 cases and deaths for each US state at a weekly level for a forecast horizon of 1-4 weeks. The model is heavily data driven, and relies on epidemiological, mobility, survey, climate, demographic, and SARS-CoV-2 variant frequencies data. We implement a rigorous and robust evaluation of our model-specifically we report on weekly performance over a one-year period based on multiple error metrics, and explicitly assess how our model performance varies over space, chronological time, and different outbreak phases.

findingsThe proposed model is shown to consistently outperform the CDC ensemble model for all evaluation metrics in multiple spatiotemporal settings, especially for the longer-term (3 and 4 weeks ahead) forecast horizon. Our case study also highlights the potential value of variant frequencies data for use in short-term forecasting to identify forthcoming surges driven by new variants.

interpretationBased on our findings, the proposed forecasting framework improves upon the available state-of-the-art forecasting tools currently used to support public health decision making with respect to COVID-19 risk.

fundingThis work was funded the NSF Rapid Response Research (RAPID) grant Award ID 2108526 and the CDC Contract #75D30120C09570.

Indexed as

COVID-19Deep LearningBenchmarkingForecastingHumansSARS-CoV-2United StatesCoronavirusCOVID-19Deep learningForecastLSTMPandemicPredictionSARS-CoV-2State-levelUSVariant frequencies data

Identifiers

PMID36821889
PMCPMC9943054
OpenAlexW4321499165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.