Evidence map›Paper›PMID 36821008›Full record

ArticleCellular and molecular life sciences : CMLS2023

Loss of pex5 sensitizes zebrafish to fasting due to deregulated mitochondria, mTOR, and autophagy.

Sushil Bhandari, Yong-Il Kim, In-Koo Nam, KwangHeum Hong, Yunju Jo, Kyeong-Won Yoo, Weifang Liao, Jae-Young Lim, Seong-Jin Kim, Jae-Young Um and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Sushil Bhandari *Department of Medicine, Graduate School, Wonkwang University, Iksan, 54538, South Korea.
Yong-Il Kim *Department of Medicine, Graduate School, Wonkwang University, Iksan, 54538, South Korea.
In-Koo Nam *Sarcopenia Total Solution Center, Wonkwang University, Iksan, 54538, South Korea.
KwangHeum HongDepartment of Medicine, Graduate School, Wonkwang University, Iksan, 54538, South Korea.
Yunju JoSarcopenia Total Solution Center, Wonkwang University, Iksan, 54538, South Korea.
Kyeong-Won YooDepartment of Microbiology, Wonkwang University School of Medicine, Iksan, 54538, South Korea.
Weifang LiaoDepartment of Medicine, Graduate School, Wonkwang University, Iksan, 54538, South Korea.
Jae-Young LimDepartment of Medicine, Graduate School, Wonkwang University, Iksan, 54538, South Korea.
Seong-Jin KimSarcopenia Total Solution Center, Wonkwang University, Iksan, 54538, South Korea.
Jae-Young UmDepartment of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul, 02447, South Korea.
Peter K KimDepartment of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Ho Sub LeeHanbang Cardio-Renal Research Center, Wonkwang University, Iksan, 54538, South Korea.
Dongryeol RyuSarcopenia Total Solution Center, Wonkwang University, Iksan, 54538, South Korea.
Seok-Hyung KimSarcopenia Total Solution Center, Wonkwang University, Iksan, 54538, South Korea.
SeongAe KwakHanbang Cardio-Renal Research Center, Wonkwang University, Iksan, 54538, South Korea.
Raekil ParkDepartment of Biomedical Science and Engineering, Institute of Integrated Technology, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea.
Seong-Kyu ChoeDepartment of Medicine, Graduate School, Wonkwang University, Iksan, 54538, South Korea. seongkyu642@wku.ac.kr.ORCID http://orcid.org/0000-0002-2102-973X
Wonkwang University · KRGwangju Institute of Science and Technology · KRKyung Hee University · KRUniversity of Toronto · CAWonkwang University Hospital · KR

Funding

Korea Institute of Marine Science and Technology promotion MOF-No. 20180430National Research Foundation of Korea 2017R1A5A2015805National Research Foundation of Korea 2019R1I1A3A01061491National Research Foundation of Korea 2021R1A5A8029876National Research Foundation of Korea 2022R1A2C2005930
6 · The paper itself

Abstract

Animal models have been utilized to understand the pathogenesis of Zellweger spectrum disorders (ZSDs); however, the link between clinical manifestations and molecular pathways has not yet been clearly established. We generated peroxin 5 homozygous mutant zebrafish (pex5

Indexed as

FastingMitochondriaPeroxisome-Targeting Signal 1 ReceptorZebrafishAnimalsAutophagyHumansMechanistic Target of Rapamycin Complex 1PeroxisomesTOR Serine-Threonine KinasesMechanistic Target of Rapamycin Complex 1MTOR protein, humanPeroxisome-Targeting Signal 1 ReceptorTOR Serine-Threonine KinasesAutophagyFastingMitochondriamTORpex5Zellweger spectrum disorder

Identifiers

PMID36821008
PMCPMC9950184
OpenAlexW4321612257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.