Evidence map›Paper›PMID 36820939›Full record

SynthesisAnnals of surgical oncology2023

Novel Mediastinoscope-Assisted Minimally Invasive Esophagectomy for Esophageal Cancer: A Systematic Review and Meta-analysis.

Anas Dabsha, Ismail A M H Elkharbotly, Mohammad Yaghmour, Amr Badr, Fady Badie, Sherif Khairallah, Yomna M Esmail, Shon Shmushkevich, Mohamed Hossny, Amr Rizk and 4 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Annals of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Anas Dabsha *Cardiothoracic Surgery Department, Weill Cornell Medicine, New York, NY, USA.
Ismail A M H Elkharbotly *Surgical Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Mohammad YaghmourCardiothoracic Surgery Department, Weill Cornell Medicine, New York, NY, USA.
Amr BadrEl Ruwaisat Family Medical Center, Sharm Elsheikh, Egypt.
Fady BadieGeneral Surgery Department, Kasr Al-ainy School of Medicine, Cairo University, Cairo, Egypt.
Sherif KhairallahCardiothoracic Surgery Department, Weill Cornell Medicine, New York, NY, USA.
Yomna M EsmailCardiothoracic Surgery Department, Weill Cornell Medicine, New York, NY, USA.
Shon ShmushkevichCardiothoracic Surgery Department, Weill Cornell Medicine, New York, NY, USA.
Mohamed HossnyCardiothoracic Surgery Department, Weill Cornell Medicine, New York, NY, USA.
Amr RizkCardiothoracic Surgery Department, Weill Cornell Medicine, New York, NY, USA.
Amgad IshakCardiothoracic Surgery Department, Weill Cornell Medicine, New York, NY, USA.
Jessica WrightCardiothoracic Surgery Department, Weill Cornell Medicine, New York, NY, USA.
Abdelrahman MohamedSurgical Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Mohamed Rahouma *Cardiothoracic Surgery Department, Weill Cornell Medicine, New York, NY, USA. mhmdrahouma@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMinimally invasive surgery is an expanding field of surgery that has replaced many open surgical techniques. Surgery remains a cornerstone in the treatment of esophageal cancer, yet it is still associated with significant morbidity and technical difficulties. Mediastinoscope-assisted esophagectomy is a promising technique that aims to decrease the surgical burden and enhance recovery.

methodsPubMed, MEDLINE, and EMBASE databases were searched for publications on mediastinoscope-assisted esophagectomies for esophageal cancer. The primary endpoint was a postoperative anastomotic leak, while secondary endpoints were assessment of harvested lymph nodes (LNs), blood loss, chyle leak, hospital length of stay (LOS), operative (OR) time, pneumonia, wound infection, mortality, and microscopic positive margin (R1). The pooled event rate (PER) and pooled mean were calculated for binary and continuous outcomes respectively.

resultsTwenty-six out of the 2274 searched studies were included. The pooled event rate (PER) for anastomotic leak was 0.145 (0.1144; 0.1828). The PERs for chyle leak, recurrent laryngeal nerve injury/hoarseness, postoperative pneumonia, wound infection, early mortality, postoperative morbidity, and microscopically positive (R1) resection margins were 0.027, 0.185, 0.09, 0.083, 0.020, 0.378, and 0.037 respectively. The pooled means for blood loss, hospital stay, operative time, number of total harvested LNs, and number of harvested thoracic LNs were 159.209, 15.187, 311.116, 23.379, and 15.458 respectively.

conclusionsMediastinoscopic esophagectomy is a promising minimally invasive technique, avoiding thoracotomy, patient repositioning, and lung manipulation; thus allowing for shorter surgery, decreased blood loss, and decreased postoperative morbidity. It can also be reliable in terms of oncological safety and LN dissection.

Indexed as

Esophageal NeoplasmsLaparoscopyPneumoniaAnastomotic LeakEsophagectomyHumansLength of StayMediastinoscopesMinimally Invasive Surgical ProceduresPostoperative ComplicationsTreatment Outcome

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.