Evidence map›Paper›PMID 36820702›Full record

ArticleActa cirurgica brasileira2023

Does low-intensity pulsed ultrasound accelerate phasic calcium phosphate ceramic-induced bone formation?

Lanying Sun, Xiaoshuang Guo, Qibao Wang, Zhongshuai Shang, Yi Du, Guodong Song

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Article in Acta cirurgica brasileira, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lanying SunJinan Stomatological Hospital - Oral Implantology Center - Jinan, China.ORCID http://orcid.org/0000-0003-4833-4846
Xiaoshuang GuoPlastic Surgery Hospital - Oral and Maxillofacial Surgery Department - Chinese Academy of Medical Sciences & Peking Union Medical College - Beijing, China.ORCID http://orcid.org/0000-0002-8834-0813
Qibao WangJinan Stomatological Hospital - Department of Endodontics - Jinan, China.ORCID http://orcid.org/0000-0002-7044-9490
Zhongshuai ShangJinan Stomatological Hospital - Oral Implantology Center - Jinan, China.ORCID http://orcid.org/0000-0001-6357-5176
Yi DuJinan Stomatological Hospital - Department of Endodontics - Jinan, China.ORCID http://orcid.org/0000-0003-1363-3977
Guodong SongPlastic Surgery Hospital - Oral and Maxillofacial Surgery Department - Chinese Academy of Medical Sciences & Peking Union Medical College - Beijing, China.ORCID http://orcid.org/0000-0002-3975-1894

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLow-intensity pulsed ultrasound (LIPUS) has been used to stimulate the healing of the fresh fracture, delayed union, and non-union in both animal and clinical studies. Besides, biphasic calcium phosphate ceramic (BCP) is a promising biomaterial for bone repair as it shows favorable biocompatibility, osteoinduction, and osteoconduction. However, scarcity is known about the combined effect of LIPUS and BCP on bone formation.

methodsThe combined effect of LIPUS and BCP was studied in a beagle model. Twelve dogs were used. BCP granules without any additions were implanted into bilateral erector spinae muscles. One side is the BCP group, while the counterlateral side is LIPUS + BCP group. Histological and histomorphometric analyses, and quantitative real-time polymerase chain reaction were evaluated.

resultsCompared with BCP alone, the LIPUS + BCP showed no advantages in early bone formation. Furthermore, the Notch signaling pathway-related mRNA has no significant difference between the two groups.

conclusionsThe preliminary results showed that the BCP, which has intrinsic osteoinduction nature, was an effective and promising material. However, LIPUS has no enhanced effect in BCP induced ectopic bone formation. Furthermore, LIPUS has no effect on the Notch signaling pathway. Whether costly LIPUS could be used in combination with BCP should be a rethink.

Indexed as

OsteogenesisUltrasonic TherapyAnimalsBone RegenerationCalcium PhosphatesCeramicsDogsHydroxyapatitesUltrasonic Wavescalcium phosphateCalcium Phosphateshydroxyapatite-beta tricalcium phosphateHydroxyapatites

Identifiers

PMID36820702
PMCPMC10037561

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