ArticleeLife2023
CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles.
Open access · goldFull text read
In one paragraph
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Kv2-VAP interactions enhance presynaptic ER and mitochondrial calcium influx and the mobilization of vesicles from the reserve pool.bioRxiv : the preprint server for biology · 2026Article
- The nanoscale mobility of calcium channels is driven by readily releasable synaptic vesicles to support precise neurotransmission in livebioRxiv : the preprint server for biology · 2026Article
- α-Synuclein oligomers slow down action potential firing and enhance dopamine release by increasing Cav2.2 currents in midbrain dopaminergic neurons.The Journal of physiology · 2026Article
- The Electromechanical Connectome: Integrating Voltage, Mechanical Nano-Forces, and Subcellular Fluid Phase Dynamics in Human Neural Computation.International journal of molecular sciences · 2026Review
- Formation, Organization, and Maintenance of Synaptic Vesicle Pools: From Molecules to Structure and Dynamics.Advances in neurobiology · 2026Review
- Presenilin Loss Impairs Synaptic Transmission and Causes Axonal Degeneration through Ryanodine Receptor Dysfunction, Independent of γ-Secretase Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteostatic Collapse, and Network Failure Across the CNS.Biomedicines · 2025Review
- Review
- Intracellular protein-lipid interactions drive presynaptic assembly prior to neurexin recruitment.Neuron · 2025Article
- TheThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Review
- Blobby is a synaptic active zone assembly protein required for memory in Drosophila.Nature communications · 2025Article
- Comprehensive Gene Expression Analysis Using Human Induced Pluripotent Stem Cells Derived from Patients with Sleep Bruxism: A Preliminary In Vitro Study.International journal of molecular sciences · 2024Article
- On the targeting of voltage-gated calcium channels to neurotransmitter release sites.Current opinion in neurobiology · 2024Review
- Pathogenicity of de novo CACNA1D CaEuropean journal of human genetics : EJHG · 2024Article
- Presynaptic neurons self-tune by inversely coupling neurotransmitter release with the abundance of CaV2 voltage-gated CaProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Using Localization Microscopy to Quantify Calcium Channels at Presynaptic Boutons.Bio-protocol · 2024Article
- RIM and RIM-Binding Protein Localize Synaptic CaV2 Channels to Differentially Regulate Transmission in Neuronal Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Selective dopaminergic neurotoxicity modulated by inherent cell-type specific neurobiology.Neurotoxicology · 2024Review
- Post-synaptic GABACell reports · 2023Article
Corrections and comments
- Commented on by
Authors and funding
13 authors at 3 institutions in 1 country.
Brian D Mueller *Howard Hughes Medical Institute, School of Biological Sciences, University of Utah, Salt Lake City, United States.ORCID https://orcid.org/0000-0002-6525-7101
Sean A Merrill *Howard Hughes Medical Institute, School of Biological Sciences, University of Utah, Salt Lake City, United States.
Shigeki WatanabeHoward Hughes Medical Institute, School of Biological Sciences, University of Utah, Salt Lake City, United States.ORCID https://orcid.org/0000-0001-7580-8141
Ping LiuDepartment of Neuroscience, University of Connecticut Medical School, Farmington, United States.
Longgang NiuDepartment of Neuroscience, University of Connecticut Medical School, Farmington, United States.ORCID https://orcid.org/0000-0001-7209-7436
Anish SinghHoward Hughes Medical Institute, School of Biological Sciences, University of Utah, Salt Lake City, United States.
Pablo Maldonado-CatalaDepartment of Neurobiology, University of Utah, Salt Lake City, United States.
Alex CherryHoward Hughes Medical Institute, School of Biological Sciences, University of Utah, Salt Lake City, United States.
Matthew S RichHoward Hughes Medical Institute, School of Biological Sciences, University of Utah, Salt Lake City, United States.
Malan SilvaHoward Hughes Medical Institute, School of Biological Sciences, University of Utah, Salt Lake City, United States.
Andres Villu MaricqDepartment of Neurobiology, University of Utah, Salt Lake City, United States.
Zhao-Wen WangDepartment of Neuroscience, University of Connecticut Medical School, Farmington, United States.ORCID https://orcid.org/0000-0003-3574-8556
Erik M JorgensenHoward Hughes Medical Institute, School of Biological Sciences, University of Utah, Salt Lake City, United States.ORCID https://orcid.org/0000-0002-2978-8028
Howard Hughes Medical Institute · USUniversity of Connecticut · USUniversity of Utah · US
Funding
Synaptic function of BK channel-interacting proteinsR01MH085927 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ZHAO-WEN WANG · 2010 to 2026
$6.7MSYNAPTIC FUNCTION IN THE NEMATODE C. ELEGANSR01NS034307 · NINDS · UNIVERSITY OF UTAH · PI JORGENSEN, ERIK M · 1995 to 2024
$5.8MRegulation of NMDAR-Mediated Synaptic SignalingR01NS125359 · NINDS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Andres Villu Maricq · 2022 to 2026
$2.6MThe function of gap junctions and chemical synapses in a simple neural circuitR01NS109388 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI WANG, ZHAO-WEN · 2018 to 2022
$2.0MGlutamate-Mediated Neurotransmission and the Control of BehaviorR01NS094421 · NINDS · UNIVERSITY OF UTAH · PI MARICQ, ANDRES VILLU · 2015 to 2019
$1.6MSynaptic Calcium ChannelsF31NS084826 · NINDS · UNIVERSITY OF UTAH · PI MERRILL, SEAN ARIC · 2013 to 2015
$86kHoward Hughes Medical InstituteNIH HHS F31 NS084826NIH HHS R01 MH085927NIH HHS R01 NS034307NIH HHS R01 NS094421NIH HHS R01 NS109388NIMH NIH HHS R01 MH085927NINDS NIH HHS F31 NS084826NINDS NIH HHS R01 NS034307NINDS NIH HHS R01 NS094421NINDS NIH HHS R01 NS109388NINDS NIH HHS R01 NS125359
Abstract
Activation of voltage-gated calcium channels at presynaptic terminals leads to local increases in calcium and the fusion of synaptic vesicles containing neurotransmitter. Presynaptic output is a function of the density of calcium channels, the dynamic properties of the channel, the distance to docked vesicles, and the release probability at the docking site. We demonstrate that at
Indexed as
Caenorhabditis elegansRyanodine Receptor Calcium Release ChannelSynaptic VesiclesAnimalsCalciumNeurotransmitter AgentsPresynaptic TerminalsSynaptic TransmissionCalciumNeurotransmitter AgentsRyanodine Receptor Calcium Release Channelcalcium channelsC. elegansL-typeMunc13neuroscienceN-typeryanodine receptorsuper-resolution microscopy
Identifiers
What OpenQuestion holds
Textfull text, public
LicenceCC BY
measurements read111
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.