Evidence map›Paper›PMID 36820096›Full record

ArticleEClinicalMedicine2023

Air pollution and decreased bone mineral density among Women's Health Initiative participants.

Diddier Prada, Carolyn J Crandall, Allison Kupsco, Marianthi-Anna Kioumourtzoglou, James D Stewart, Duanping Liao, Jeff D Yanosky, Andrea Ramirez, Jean Wactawski-Wende, Yike Shen and 4 more

Open access · goldAbstract read
In one paragraph

Article in EClinicalMedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Observational
  3. Ovarian hormone deficiency enhances wood smoke-induced immune dysfunction via transcriptomic and metabolic alterations.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  4. Article
  5. Article
  6. Metabolomic evaluation of air pollution-related bone damage and potential mediation in Women's Health Initiative participants.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Article
  7. Article
  8. Article
  9. Exposure to air pollution might decrease bone mineral density and increase the prevalence of osteoporosis: a Mendelian randomization study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Article
  10. Air Pollution and Osteoporosis.Current osteoporosis reports · 2024
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Breathing Easy for Better Bones: The Undervalued Role of Air Quality in Bone Health.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Diddier PradaDepartment of Environmental Health Science, Mailman School of Public Health, Columbia University, New York, NY, USA.
Carolyn J CrandallDivision of General Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California, Los Angeles, CA, USA.
Allison KupscoDepartment of Environmental Health Science, Mailman School of Public Health, Columbia University, New York, NY, USA.
Marianthi-Anna KioumourtzoglouDepartment of Environmental Health Science, Mailman School of Public Health, Columbia University, New York, NY, USA.
James D StewartDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Duanping LiaoDepartment of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Jeff D YanoskyDepartment of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Andrea RamirezInstituto Nacional de Cancerología - México, Mexico City, Mexico.
Jean Wactawski-WendeSchool of Public Health and Health Professions, University at Buffalo, State University of New York, New York, USA.
Yike ShenDepartment of Environmental Health Science, Mailman School of Public Health, Columbia University, New York, NY, USA.
Gary MillerDepartment of Environmental Health Science, Mailman School of Public Health, Columbia University, New York, NY, USA.
Iuliana Ionita-LazaDepartment of Environmental Health Science, Mailman School of Public Health, Columbia University, New York, NY, USA.
Eric A WhitselDepartment of Epidemiology, Gillings School of Global Public Health and Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Andrea A BaccarelliDepartment of Environmental Health Science, Mailman School of Public Health, Columbia University, New York, NY, USA.
Columbia University · USInstituto Nacional de Cancerología · MXPennsylvania State University · USUniversity of North Carolina at Chapel Hill · USUniversity at Buffalo, State University of New York · USUniversity of California, Los Angeles · US

Funding

WOMEN'S HEALTH INITIATIVE - CLINICAL COORDINATING CENTER: TASK AREA B - LONG LIFE STUDY VISIT 2 LIMITED HOME VISIT75N92021D00001 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L. · 2021 to 2025
$52.0M
True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC): TASK AREA A AND A275N92021D00002 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WACTAWSKI-WENDE, JEAN · 2021 to 2025
$6.9M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00004 · NHLBI · STANFORD UNIVERSITY · PI STEFANICK, MARCIA · 2021 to 2025
$6.5M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00003 · NHLBI · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA · 2021 to 2025
$5.0M
Extracellular vesicles in Environmental Epidemiology Studies of AgingR35ES031688 · NIEHS · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Andrea Baccarelli · 2021 to 2026
$4.6M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI VITOLINS, MARA · 2021 to 2025
$4.2M
Blood mitochondrial DNA biomarkers of midlife cognitive decline and adverse brain imaging changes - A longitudinal investigation in the CARDIA population‐based cohort studyR01AG069120 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HOU, LIFANG, YAFFE, KRISTINE · 2020 to 2024
$4.0M
Air Particulate, Metals, and Cognitive Performance in an Aging Cohort- Roles of Circulating Extracellular Vesicles and Non-coding RNAsR01ES027747 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI SCHWARTZ, JOEL D · 2017 to 2021
$3.7M
U2C Experimental CoreU2CES030163 · NIEHS · EMORY UNIVERSITY · PI JONES, DEAN PAUL, LI, SHUZHAO · 2018 to 2021
$3.6M
Stress, Epigenetics and AgingR01AG058704 · NIA · EMORY UNIVERSITY · PI SHELTON, RACHEL C, SUGLIA, SHAKIRA FRANCO · 2018 to 2022
$3.4M
NCATS NIH HHS R43 TR000187NCATS NIH HHS R44 TR000187NHLBI NIH HHS 75N92021D00001NHLBI NIH HHS 75N92021D00002NIA NIH HHS R01 AG058704NIA NIH HHS R01 AG069120NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R00 ES030749NIEHS NIH HHS R01 ES020836NIEHS NIH HHS R01 ES025225NIEHS NIH HHS R01 ES027747NIEHS NIH HHS R01 ES028805NIEHS NIH HHS R01 ES029943NIEHS NIH HHS R01 ES030616NIEHS NIH HHS R01 ES032242NIEHS NIH HHS R35 ES031688NIEHS NIH HHS U2C ES030163WHI NIH HHS 75N92021D00003WHI NIH HHS 75N92021D00004WHI NIH HHS 75N92021D00005
6 · The paper itself

Abstract

Background: Osteoporosis heavily affects postmenopausal women and is influenced by environmental exposures. Determining the impact of criteria air pollutants and their mixtures on bone mineral density (BMD) in postmenopausal women is an urgent priority. Methods: We conducted a prospective observational study using data from the ethnically diverse Women's Health Initiative Study (WHI) (enrollment, September 1994-December 1998; data analysis, January 2020 to August 2022). We used log-normal, ordinary kriging to estimate daily mean concentrations of PM Findings: In cross-sectional and longitudinal analyses, mean PM Interpretation: In this cohort study, higher levels of air pollutants were associated with bone damage, particularly on lumbar spine, among postmenopausal women. These findings highlight nitrogen oxides exposure as a leading contributor to bone loss in postmenopausal women, expanding previous findings of air pollution-related bone damage. Funding: US National Institutes of Health.

Indexed as

Air pollutionBone damageBone mineral densityMixturesPostmenopause

Identifiers

PMID36820096
PMCPMC9938170
OpenAlexW4320928774

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.