Evidence map›Paper›PMID 36820079›Full record

ArticleERJ open research2023

Characteristics and risk factors for post-COVID-19 breathlessness after hospitalisation for COVID-19.

Luke Daines, Bang Zheng, Omer Elneima, Ewen Harrison, Nazir I Lone, John R Hurst, Jeremy S Brown, Elizabeth Sapey, James D Chalmers, Jennifer K Quint and 23 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Review
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Article
  9. Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study.International journal of epidemiology · 2024
    Article
  10. Article
  11. Article
  12. Predictors of reduced incremental shuttle walk test performance in patients with long post-COVID-19.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 15 institutions in 1 country.

Luke DainesUsher Institute, University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0003-0564-4000
Bang ZhengUsher Institute, University of Edinburgh, Edinburgh, UK.
Omer ElneimaThe Institute for Lung Health, Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester, UK.
Ewen HarrisonUsher Institute, University of Edinburgh, Edinburgh, UK.
Nazir I LoneUsher Institute, University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0003-2707-2779
John R HurstUCL Respiratory, University College London, London, UK.ORCID https://orcid.org/0000-0002-7246-6040
Jeremy S BrownUCL Respiratory, University College London, London, UK.
Elizabeth SapeyCentre for Translational Inflammation Research, University of Birmingham, Birmingham, UK.ORCID https://orcid.org/0000-0003-3454-5482
James D ChalmersSchool of Medicine, University of Dundee, Dundee, UK.
Jennifer K QuintNational Heart and Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0003-0149-4869
Paul PfefferBarts Health NHS Trust and Queen Mary University of London, London, UK.
Salman SiddiquiThe Institute for Lung Health, Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester, UK.
Samantha WalkerAsthma + Lung UK, London, UK.
Krisnah PoinasamyAsthma + Lung UK, London, UK.
Hamish McAuleyThe Institute for Lung Health, Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0001-8997-0764
Marco SerenoThe Institute for Lung Health, Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester, UK.
Aarti ShikotraThe Institute for Lung Health, Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester, UK.
Amisha SingapuriThe Institute for Lung Health, Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester, UK.
Annemarie B DochertyUsher Institute, University of Edinburgh, Edinburgh, UK.
Michael MarksClinical Research Department, London School of Hygiene and Tropical Medicine, London, UK.ORCID https://orcid.org/0000-0002-7585-4743
Mark ToshnerHeart Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0002-3969-6143
Luke S HowardHammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK.ORCID https://orcid.org/0000-0003-2822-210X
Alex HorsleyDivision of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0003-1828-0058
Gisli JenkinsNational Heart and Lung Institute, Imperial College London, London, UK.
Joanna C PorterUCL Respiratory, University College London, London, UK.ORCID https://orcid.org/0000-0002-7307-169X
Ling-Pei HoMRC Weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK.
Betty RamanRadcliffe Department of Medicine, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-1239-9608
Louise V WainDepartment of Health Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0003-4951-1867
Christopher E BrightlingThe Institute for Lung Health, Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester, UK.
Rachael A EvansThe Institute for Lung Health, Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0002-1667-868X
Liam G HeaneyCentre for Experimental Medicine, Queen's University Belfast, Belfast, UK.
Anthony De SoyzaPopulation Health Science Institute, Newcastle University, Newcastle, UK.ORCID https://orcid.org/0000-0002-8566-0344
Aziz SheikhUsher Institute, University of Edinburgh, Edinburgh, UK.
University of Leicester · GBUniversity of Edinburgh · GBUniversity College London · GBBritish Lung Foundation · GBImperial College London · GBUniversity of Oxford · GBCentre for Inflammation Research · GBImperial College Healthcare NHS Trust · GBLondon School of Hygiene & Tropical Medicine · GBNewcastle University · GBQueen Mary University of London · GBQueen's University Belfast · GBUniversity of Cambridge · GBUniversity of Dundee · GBUniversity of Manchester · GB

Funding

Medical Research Council MC_PC_19004Medical Research Council MR/V027859/1Medical Research Council MR/W006111/1
6 · The paper itself

Abstract

Background: Persistence of respiratory symptoms, particularly breathlessness, after acute coronavirus disease 2019 (COVID-19) infection has emerged as a significant clinical problem. We aimed to characterise and identify risk factors for patients with persistent breathlessness following COVID-19 hospitalisation. Methods: PHOSP-COVID is a multicentre prospective cohort study of UK adults hospitalised for COVID-19. Clinical data were collected during hospitalisation and at a follow-up visit. Breathlessness was measured by a numeric rating scale of 0-10. We defined post-COVID-19 breathlessness as an increase in score of ≥1 compared to the pre-COVID-19 level. Multivariable logistic regression was used to identify risk factors and to develop a prediction model for post-COVID-19 breathlessness. Results: We included 1226 participants (37% female, median age 59 years, 22% mechanically ventilated). At a median 5 months after discharge, 50% reported post-COVID-19 breathlessness. Risk factors for post-COVID-19 breathlessness were socioeconomic deprivation (adjusted OR 1.67, 95% CI 1.14-2.44), pre-existing depression/anxiety (adjusted OR 1.58, 95% CI 1.06-2.35), female sex (adjusted OR 1.56, 95% CI 1.21-2.00) and admission duration (adjusted OR 1.01, 95% CI 1.00-1.02). Black ethnicity (adjusted OR 0.56, 95% CI 0.35-0.89) and older age groups (adjusted OR 0.31, 95% CI 0.14-0.66) were less likely to report post-COVID-19 breathlessness. Post-COVID-19 breathlessness was associated with worse performance on the shuttle walk test and forced vital capacity, but not with obstructive airflow limitation. The prediction model had fair discrimination (concordance statistic 0.66, 95% CI 0.63-0.69) and good calibration (calibration slope 1.00, 95% CI 0.80-1.21). Conclusions: Post-COVID-19 breathlessness was commonly reported in this national cohort of patients hospitalised for COVID-19 and is likely to be a multifactorial problem with physical and emotional components.

Identifiers

PMID36820079
PMCPMC9790090
OpenAlexW4312076984

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.