Evidence map›Paper›PMID 36820030›Full record

ArticleHeliyon2023

PLODs: Novel prognostic biomarkers and potential immunotherapy targets for head and neck squamous cell carcinoma.

Siming Gong, Changwu Wu, Yingjuan Duan, Jinfei Fu, Yuling Wang, Hao Wu, Bixi Zhang, Juyu Tang, Panfeng Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Siming GongDepartment of Hand and Microsurgery, Department of Orthopedics, Xiangya Hospital of Central South University, Changsha, China.
Changwu WuInstitute of Anatomy, University of Leipzig, Leipzig, Germany.
Yingjuan DuanFaculty of Chemistry and Mineralogy, University of Leipzig, Leipzig, Germany.
Jinfei FuDepartment of Hand and Microsurgery, Department of Orthopedics, Xiangya Hospital of Central South University, Changsha, China.
Yuling WangDepartment of Hand and Microsurgery, Department of Orthopedics, Xiangya Hospital of Central South University, Changsha, China.
Hao WuDepartment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha, China.
Bixi ZhangDepartment of Pathology, Hunan Provincial People's Hospital, Hunan Normal University, Changsha, China.
Juyu TangDepartment of Hand and Microsurgery, Department of Orthopedics, Xiangya Hospital of Central South University, Changsha, China.
Panfeng WuDepartment of Hand and Microsurgery, Department of Orthopedics, Xiangya Hospital of Central South University, Changsha, China.
Central South University · CNLeipzig University · DEHunan Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck squamous cell carcinoma (HNSCC) comprise a group of malignant tumors arising from the squamous epithelium of the oral cavity, pharynx, and larynx. HNSCC is the 6th most common cancer in the world, with approximately 650,000 new cases and 400,000 deaths annually. Although survival rates have improved, HNSCC therapy may result in short - or long-term morbidity in approximately 50% of cases. Previous studies have also indicated that the overexpression of procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenases (PLOD) family proteins could lead to certain diseases or even tumors. However, there has been no dedicated evaluation of the relationship between PLOD family members and HNSCC. Here we used data from the Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and Human Protein Atlas (HPA) databases to explore the potential role of PLOD family proteins in HNSCC. Our evaluations suggest that increased expression of PLOD family proteins may be associated with poorer prognosis and increased immune infiltration in HNSCC, making these proteins a potential biomarker for personalized treatment of HNSCC.

Indexed as

Head and neck squamous cell carcinomaImmune infiltrationImmunotherapyPLODsPrognosticTumor microenvironment

Identifiers

PMID36820030
PMCPMC9937984
OpenAlexW4318938980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.