Evidence map›Paper›PMID 36820004›Full record

ReviewCurrent treatment options in neurology2023

Diagnosis and Management of Posterior Cortical Atrophy.

Keir X X Yong, Jonathan Graff-Radford, Samrah Ahmed, Marianne Chapleau, Rik Ossenkoppele, Deepti Putcha, Gil D Rabinovici, Aida Suarez-Gonzalez, Jonathan M Schott, Sebastian Crutch and 1 more

Open access · hybridAbstract readReview
In one paragraph

Review in Current treatment options in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 42 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. International journal of molecular sciences · 2025
    Article
  10. A 2025 update on treatment strategies for the Alzheimer's disease spectrum.Journal of the Chinese Medical Association : JCMA · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. An uncommon variant of Alzheimer's disease: Posterior cortical atrophy.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2025
    Article
  15. Atypical Presentations of Alzheimer Disease.Continuum (Minneapolis, Minn.) · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Observational
  20. Rehabilitation Services for Young-Onset Dementia: Examples from High- and Low-Middle-Income Countries.International journal of environmental research and public health · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Keir X X YongDementia Research Centre, UCL Queen Square Institute of Neurology, Box 16, Queen Square, London, WC1N 3BG UK.ORCID 0000-0002-9708-3599
Jonathan Graff-RadfordDepartment of Neurology, Mayo Clinic, Rochester, MN USA.
Samrah AhmedNuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK.
Marianne ChapleauMemory and Aging Center, University of California San Francisco, San Francisco, CA USA.
Rik OssenkoppeleAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, Netherlands.
Deepti PutchaFrontotemporal Disorders Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA.
Gil D RabinoviciDepartment of Neurology, Radiology, and Biomedical Imaging, University of California San Francisco, San Francisco, CA USA.
Aida Suarez-GonzalezDementia Research Centre, UCL Queen Square Institute of Neurology, Box 16, Queen Square, London, WC1N 3BG UK.
Jonathan M SchottDementia Research Centre, UCL Queen Square Institute of Neurology, Box 16, Queen Square, London, WC1N 3BG UK.
Sebastian CrutchDementia Research Centre, UCL Queen Square Institute of Neurology, Box 16, Queen Square, London, WC1N 3BG UK.
Emma HardingDementia Research Centre, UCL Queen Square Institute of Neurology, Box 16, Queen Square, London, WC1N 3BG UK.
NIHR Queen Square Dementia Biomedical Research Unit · GBUniversity of California, San Francisco · USHarvard University · USLund University · SEMayo Clinic · USUniversity of Oxford · GB

Funding

Reimagining Precision Medicine Approaches to AD DiagnosisR35AG072362 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POSSIN, KATHERINE LAUREL, RABINOVICI, GIL DAN · 2021 to 2025
$4.8M
NIA NIH HHS R35 AG072362Wellcome Trust
6 · The paper itself

Abstract

Purpose of review: The study aims to provide a summary of recent developments for diagnosing and managing posterior cortical atrophy (PCA). We present current efforts to improve PCA characterisation and recommendations regarding use of clinical, neuropsychological and biomarker methods in PCA diagnosis and management and highlight current knowledge gaps. Recent findings: Recent multi-centre consensus recommendations provide PCA criteria with implications for different management strategies (e.g. targeting clinical features and/or disease). Studies emphasise the preponderance of primary or co-existing Alzheimer's disease (AD) pathology underpinning PCA. Evidence of approaches to manage PCA symptoms is largely derived from small studies. Summary: PCA diagnosis is frequently delayed, and people are likely to receive misdiagnoses of ocular or psychological conditions. Current treatment of PCA is symptomatic - pharmacological and non-pharmacological - and the use of most treatment options is based on small studies or expert opinion. Recommendations for non-pharmacological approaches include interdisciplinary management tailored to the PCA clinical profile - visual-spatial - rather than memory-led, predominantly young onset - and psychosocial implications. Whilst emerging disease-modifying treatments have not been tested in PCA, an accurate and timely diagnosis of PCA and determining underlying pathology is of increasing importance in the advent of disease-modifying therapies for AD and other albeit rare causes of PCA.

Indexed as

Alzheimer’s diseaseAtypical Alzheimer’s diseasePosterior cortical atrophyTreatmentVisual processingVisual variant Alzheimer’s disease

Identifiers

PMID36820004
PMCPMC9935654
OpenAlexW4319596989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.