ArticleBrain communications2023
Postoperative delirium is associated with grey matter brain volume loss.
Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Quantitative Electroencephalogram Changes before and after Postoperative Delirium: A Prospective, Multicenter Cohort Study.Anesthesiology · 2026Article
- Delirium versus encephalopathy: a call for precise terminology.Intensive care medicine · 2026Article
- Linking cortical structure and delirium in the elderly: insights from cohort study and shared genetic risk analysis.Journal of translational medicine · 2026Article
- Brain Microstructural Alteration and Its Implications for Postoperative Delirium in Elderly Surgical Patients: A Narrative Review.Brain and behavior · 2025Review
- Preoperative brain volume loss is associated with postoperative delirium in advanced heart failure patients supported by left ventricular assist device.Scientific reports · 2025Article
- Role of glia in delirium: proposed mechanisms and translational implications.Molecular psychiatry · 2025Review
- Emerging biomarkers of postoperative delirium at the intersection of neuroinflammation and neurodegeneration.Frontiers in aging neuroscience · 2025Review
- The Relationship between Delirium and Dementia.Seminars in neurology · 2024Review
- Relationship between cortical brain atrophy, delirium, and long-term cognitive decline in older surgical patients.Neurobiology of aging · 2024Article
- Structural disconnectivity in postoperative delirium: A perioperative two-center cohort study in older patients.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Perioperative Levels of IL8 and IL18, but not IL6, are Associated with Nucleus Basalis Magnocellularis Atrophy Three Months after Surgery.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024Article
- Distinct brain and neurocognitive transformations after bariatric surgery: a pilot study.Frontiers in neuroscience · 2024Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Delirium is associated with long-term cognitive dysfunction and with increased brain atrophy. However, it is unclear whether these problems result from or predisposes to delirium. We aimed to investigate preoperative to postoperative brain changes, as well as the role of delirium in these changes over time. We investigated the effects of surgery and postoperative delirium with brain MRIs made before and 3 months after major elective surgery in 299 elderly patients, and an MRI with a 3 months follow-up MRI in 48 non-surgical control participants. To study the effects of surgery and delirium, we compared brain volumes, white matter hyperintensities and brain infarcts between baseline and follow-up MRIs, using multiple regression analyses adjusting for possible confounders. Within the patients group, 37 persons (12%) developed postoperative delirium. Surgical patients showed a greater decrease in grey matter volume than non-surgical control participants [linear regression: B (95% confidence interval) = -0.65% of intracranial volume (-1.01 to -0.29,
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