Evidence map›Paper›PMID 36819932›Full record

ReviewTopics in spinal cord injury rehabilitation2023

Transcutaneous Spinal Stimulation From Adults to Children: A Review.

Goutam Singh, Kathryn Lucas, Anastasia Keller, Rebecca Martin, Andrea Behrman, Sergey Vissarionov, Yury P Gerasimenko

Open access · greenAbstract readReview
In one paragraph

Review in Topics in spinal cord injury rehabilitation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Goutam SinghKosair Charities School of Physical Therapy, Spalding University, Louisville, Kentucky.
Kathryn LucasKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, Kentucky.
Anastasia KellerDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California.
Rebecca MartinInternational Center for Spinal Cord Injury, Hugo W. Moser Research Institute at Kennedy Krieger Institute, Baltimore, Maryland.
Andrea BehrmanKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, Kentucky.
Sergey VissarionovTurner Scientific Research Institute for Children's Orthopedics, St. Petersburg, Russia.
Yury P GerasimenkoKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, Kentucky.
University of Louisville · USJohns Hopkins Medicine · USKosair Charities · USNeurological Surgery · USThe Turner Scientific Research Institute for Children's Orthopedics · RUUniversity of California, San Francisco · US

Funding

Transformation of Paraplegic Paralysis to Overground Stepping in HumansR01NS102920 · NINDS · UNIVERSITY OF LOUISVILLE · PI OVECHKIN, ALEXANDER VLADIMIROVICH · 2019 to 2023
$2.8M
NINDS NIH HHS R01 NS102920
6 · The paper itself

Abstract

Neuromodulation via spinal stimulation is a promising therapy that can augment the neuromuscular capacity for voluntary movements, standing, stepping, and posture in individuals with spinal cord injury (SCI). The spinal locomotor-related neuronal network known as a central pattern generator (CPG) can generate a stepping-like motor output in the absence of movement-related afferent signals from the limbs. Using epidural stimulation (EP) in conjunction with activity-based locomotor training (ABLT), the neural circuits can be neuromodulated to facilitate the recovery of locomotor functions in persons with SCI. Recently, transcutaneous spinal stimulation (scTS) has been developed as a noninvasive alternative to EP. Early studies of scTS at thoracolumbar, coccygeal, and cervical regions have demonstrated its effectiveness in producing voluntary leg movements, posture control, and independent standing and improving upper extremity function in adults with chronic SCI. In pediatric studies, the technology of spinal neuromodulation is not yet widespread. There are a limited number of publications reporting on the use of scTS in children and adolescents with either cerebral palsy, spina bifida, or SCI.

Indexed as

Spinal Cord InjuriesAdolescentAdultChildHumansMovementPosturemotor recoveryneuromodulationpediatricspinal cord injuryspinal stimulationtranscutaneous spinal cord stimulation

Identifiers

PMID36819932
PMCPMC9936896
OpenAlexW4312039315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.