ArticlePhysical therapy research2022
Pain in Spinal Muscular Atrophy: A Questionnaire Study.
Article in Physical therapy research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The trial behind it
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Pain in adult and adolescent patients with 5q-associated Spinal Muscular Atrophy - an often underrated phenomenon.Journal of neuromuscular diseases · 2025Article
- Survey of feeding issues experienced by patients with spinal muscular atrophy type 2 in Japan.Journal of physical therapy science · 2025Article
- Cerebrospinal fluid metabolomics of pain in patients with spinal muscle atrophy.Pain medicine (Malden, Mass.) · 2025Article
- Sensory dysfunction in SMA type 2 and 3 - adaptive mechanism or concomitant target of damage?Orphanet journal of rare diseases · 2024Article
- Health-related quality of life of adults with spinal muscular atrophy: insights from a nationwide patient registry in Germany.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Chronic Pain in Patients with Spinal Muscular Atrophy in Switzerland: A Query to the Spinal Muscular Atrophy Registry.Journal of clinical medicine · 2024Article
- Pain in Children and Adolescents with Spinal Muscular Atrophy: A Longitudinal Study from a Patient Registry.Children (Basel, Switzerland) · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to reveal the chronic pain prevalence in spinal muscular atrophy (SMA) patients and identify the clinical characteristics of these patients with chronic pain. The pain status was also investigated in SMA patients with chronic pain.
methodsThis cross-sectional study was conducted between July 2018 and December 2018. SMA type II and type III patients in Japan were mailed a survey questionnaire. The survey items were chronic pain prevalence, clinical characteristics, and motor function. Patients with chronic pain also answered questions on various pain status parameters: pain intensity, frequency, duration, location using body map, and factors that exacerbated and relieved pain.
resultsThe questionnaire recovery rate was 61.1%. Sixty-four type II (mean age 17.3 ± 11.7 years) and 22 type III (mean age 44.9 ± 21.6 years) patients were eligible for inclusion. The prevalence of chronic pain in type II and III patients was 40.6% and 40.9%, respectively. Type II patients with chronic pain were more likely to report the inability to sit without manual support than those without pain (p = 0.03). Pain intensity in SMA patients was mild, but pain usually occurred daily, for prolonged durations, most often in the neck, back, and lower extremities. Sitting and high physical activity exacerbated pain the most.
conclusionThe percentage of patients with SMA with chronic pain was high, at above 40%. Moreover, the pain experienced by patients with SMA was low in intensity but frequent and most common in the lower extremities.
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