ArticleChemical science2023
Rational design of mesoporous chiral MOFs as reactive pockets in nanochannels for enzyme-free identification of monosaccharide enantiomers.
Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 49 citations in OpenAlex.
- An Amino-Acid-Derived Metal-Organic Framework with Large Pores for Unspecific Enantioseparation.Journal of the American Chemical Society · 2026Article
- Bimetallic nanotubes enhanced MALDI-TOF MS for rapid detection of carbapenemase activity in Klebsiella pneumoniae.Analytical and bioanalytical chemistry · 2025Article
- Ru@UiO-66-NHBiosensors · 2024Article
- Applications of Nanozymes in Chiral-Molecule Recognition through Electrochemical and Ultraviolet-Visible Analysis.Molecules (Basel, Switzerland) · 2024Review
- Structure-regulated enhanced Raman scattering on a semiconductor to study temperature-influenced enantioselective identification.Chemical science · 2024Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monosaccharides play significant roles in daily metabolism in living organisms. Although various devices have been constructed for monosaccharide identification, most rely on the specificity of the natural enzyme. Herein, inspired by natural ionic channels, an asymmetrical MOF-in-nanochannel architecture is developed to discriminate monosaccharide enantiomers based on cascade reactions by combining oxidase-mimicking and Fenton-like catalysis in homochiral mesoporous CuMOF pockets. The identification performance is remarkably enhanced by the increased oxidase-mimicking activity of Au nanoparticles under a local surface plasmon resonance (LSPR) excitation. The apparent steady-state kinetic parameters and nano-fluidic simulation indicate that the different affinities induced by Au-LSPR excitation and the confinement effect from MOF pockets precipitate the high chiral sensitivity. This study offers a promising strategy for designing an enantiomer discrimination device and helps to gain insight into the origin of stereoselectivity in a natural enzyme.
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Registered trials
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