Evidence map›Paper›PMID 36819664›Full record

ArticleCell genomics2023

The shared genetic landscape of blood cell traits and risk of neurological and psychiatric disorders.

Yuanhao Yang, Yuan Zhou, Dale R Nyholt, Chloe X Yap, Rudolph K Tannenberg, Ying Wang, Yang Wu, Zhihong Zhu, Bruce V Taylor, Jacob Gratten

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Yuanhao YangMater Research Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia.
Yuan ZhouMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.
Dale R NyholtSchool of Biomedical Sciences, Faculty of Health, and Centre for Genomics and Personalised Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.
Chloe X YapMater Research Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia.
Rudolph K TannenbergMater Research Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia.
Ying WangAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Yang WuInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.
Zhihong ZhuInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.
Bruce V TaylorMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.
Jacob GrattenMater Research Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia.
The University of Queensland · AUUniversity of Tasmania · AUBroad Institute · USQueensland University of Technology · AU

Funding

Medical Research Council MC_QA137853
6 · The paper itself

Abstract

Phenotypic associations have been reported between blood cell traits (BCTs) and a range of neurological and psychiatric disorders (NPDs), but in most cases, it remains unclear whether these associations have a genetic basis and, if so, to what extent genetic correlations reflect causality. Here, we report genetic correlations and Mendelian randomization analyses between 11 NPDs and 29 BCTs, using genome-wide association study summary statistics. We found significant genetic correlations for four BCT-NPD pairs, all of which have prior evidence for a phenotypic correlation. We identified a previously unreported causal effect of increased platelet distribution width on susceptibility to Parkinson's disease. We identified multiple functional genes and regulatory elements for specific BCT-NPD pairs, some of which are targets of known drugs. These results enrich our understanding of the shared genetic landscape underlying BCTs and NPDs and provide a robust foundation for future work to improve prognosis and treatment of common NPDs.

Indexed as

blood-based biomarkersblood cell traitsgenetic correlationMendelian randomizationneurological and psychiatric disordersParkinson’s diseaseplatelets

Identifiers

PMID36819664
PMCPMC9932996
OpenAlexW4319993239

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.