ArticleCell genomics2023
The human inactive X chromosome modulates expression of the active X chromosome.
Open access · goldAbstract read
In one paragraph
Article in Cell genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
30.1field-weighted citation impact, top 1% of its field
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Sex chromosome aneuploidy impacts on human gene expression and regulation: a systematic review.Molecular medicine (Cambridge, Mass.) · 2025Pooled it
- 4D nucleome landscape reveals dissolution of bipartite active X chromosome in liver cancer development.Nature cell biology · 2026Article
- Cell-type specific allelic dampening of sex-linked genes in sex chromosome aneuploidy.bioRxiv : the preprint server for biology · 2026Article
- The inactive X chromosome as a female protector in autism and beyond.Nature genetics · 2026Review
- Transcriptional mechanisms of sex-biased gene expression and their connections to disease-associated variation.Human molecular genetics · 2026Article
- Escape from X inactivation drives sex differences in gene expression.Molecular biology and evolution · 2026Article
- Escape from X inactivation varies across genes and tissues and shapes sex-biased sex chromosome gene expression.BMC genomics · 2026Article
- Knowledge gaps and research priorities to understand sex differences in immunity.PLoS biology · 2026Review
- Opportunities for RNA sequencing in physiology: from big data to understanding homeostasis and heterogeneity.Function (Oxford, England) · 2026Review
- Clinical description, genetic analysis and characterization of two NLRP12 heterozygous VUS variants.Frontiers in immunology · 2026Article
- Grand challenges in sex differences in immunology: problems the field must solve before biological sex can guide clinical practice.Frontiers in immunology · 2026Article
- A human induced pluripotent stem cell toolbox for studying sex chromosome effects.Stem cell reports · 2025Article
- SF3B1-mutant models of RNA mis-splicing uncover UBA1 as a therapeutic target in myelodysplastic neoplasms.Leukemia · 2025Article
- Transcriptomic Convergence and the Female Protective Effect in Autism.bioRxiv : the preprint server for biology · 2025Article
- XIST Loss Induces Variable Transcriptional Responses Dependent on Cell States.Non-coding RNA · 2025Article
- The inactive X chromosome as a female protector in autism and beyond.Research square · 2025Article
- Sex differences in the developing human cortex intersect with genetic risk of neurodevelopmental disorders.bioRxiv : the preprint server for biology · 2025Article
- Elevated autistic traits and social anxiety, and reduced empathy in adult women with triple X syndrome.Journal of neurodevelopmental disorders · 2025Article
- Article
- An iPSC-based model of 47,XYY Jacobs syndrome reveals a DNA methylation-independent transcriptional dysregulation shared with male X aneuploid cells.Genome research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 6 institutions in 1 country.
Adrianna K San RomanWhitehead Institute, Cambridge, MA 02142, USA.
Alexander K GodfreyWhitehead Institute, Cambridge, MA 02142, USA.
Helen SkaletskyWhitehead Institute, Cambridge, MA 02142, USA.
Daniel W BellottWhitehead Institute, Cambridge, MA 02142, USA.
Abigail F GroffWhitehead Institute, Cambridge, MA 02142, USA.
Hannah L HarrisWhitehead Institute, Cambridge, MA 02142, USA.
Laura V BlantonWhitehead Institute, Cambridge, MA 02142, USA.
Jennifer F HughesWhitehead Institute, Cambridge, MA 02142, USA.
Laura BrownWhitehead Institute, Cambridge, MA 02142, USA.
Sidaly PhouWhitehead Institute, Cambridge, MA 02142, USA.
Ashley BuscettaMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Paul KruszkaMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Nicole BanksMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Amalia DutraCytogenetics and Microscopy Core, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Evgenia PakCytogenetics and Microscopy Core, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Patricia C LasutschinkowFocus Foundation, Davidsonville, MD 21035, USA.
Colleen KeenFocus Foundation, Davidsonville, MD 21035, USA.
Shanlee M DavisDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Nicole R TartagliaDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Carole Samango-SprouseFocus Foundation, Davidsonville, MD 21035, USA.
Maximilian MuenkeMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
David C PageWhitehead Institute, Cambridge, MA 02142, USA.
Whitehead Institute for Biomedical Research · USNational Institutes of Health · USHoward Hughes Medical Institute · USChildren's Hospital Colorado · USGeorge Washington University · USUniversity of Colorado Denver · US
Funding
NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1MNHGRI/DIR Cytogenetics and Microscopy CoreZICHG200348 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI WINCOVITCH, STEPHEN · 2010 to 2025
$20.3MBeyond the reproductive tract: The future of Y chromosome researchU01HG007587 · NHGRI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI MUENKE, MAXIMILIAN, PAGE, DAVID C. · 2015 to 2017
$1.4MTESTO: Testosterone Effects on Short-Term Outcomes in Infants with XXYK23HD092588 · NICHD · UNIVERSITY OF COLORADO DENVER · PI DAVIS, SHANLEE · 2017 to 2021
$826kEffects of sex chromosome constitution on global gene expressionF32HD091966 · NICHD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI SAN ROMAN, ADRIANNA K · 2017 to 2020
$224kNCATS NIH HHS UL1 TR002535NHGRI NIH HHS U01 HG007587NICHD NIH HHS F32 HD091966NICHD NIH HHS K23 HD092588
Abstract
The "inactive" X chromosome (Xi) has been assumed to have little impact, in
Indexed as
aneuploidydosage sensitivitygene expressionKlinefelter syndromesex chromosomessex differencesturner syndromeX chromosome inactivation
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.