ArticleAnnals of translational medicine2023
Bioinformatics analysis of differentially expressed genes in diabetic foot ulcer and preliminary experimental verification.
Article in Annals of translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 7 citations in OpenAlex.
- Unveiling the therapeutic role of 3D-cultured mesenchymal stem cells in diabetic foot ulcers through transcriptomic integration and fibroblast modulation.Molecular biology reports · 2026Article
- Combined Analysis of Human and Experimental Rat Samples Identified Biomarkers for Ischemic Stroke.Molecular neurobiology · 2025Article
- Multi-omics Identify the Role of FGF7 Pathway in Diabetic Foot Ulcers.Iranian journal of pharmaceutical research : IJPRArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Molecular changes are closely related to the pathogenesis and healing process of diabetic foot ulcers (DFUs), and are crucial for the early prediction and intervention of DFU. Methods: Bioinformatics analysis was performed in this study to identify the key differentially expressed genes (DEGs) in DFU, analyze their functions and function modes, and conduct preliminary experimental verification to determine the potential pivotal genes in the pathogenesis of DFU. Two datasets, GSE68183 and GSE80178, were obtained from the Gene Expression Omnibus (GEO). DEGs were obtained using GEO2R. Six co-expressed DEGs (co-DEGs) were obtained by R language analysis. The co-DEGs were constructed by using STRING and Cytoscape 3.7.2 to construct a protein-protein interaction (PPI) network, and two hub genes, Results: Conclusions: Our study found that the
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