Evidence map›Paper›PMID 36819296›Full record

ArticleFrontiers in human neuroscience2022

Assessing awareness in severe Alzheimer's disease.

Jonathan Huntley, Daniel Bor, Feng Deng, Marco Mancuso, Pedro A M Mediano, Lorina Naci, Adrian M Owen, Lorenzo Rocchi, Avital Sternin, Robert Howard

Open access · goldAbstract read
In one paragraph

Article in Frontiers in human neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Lucidity in the Deeply Forgetful: A Scoping Review.Journal of Alzheimer's disease : JAD · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Jonathan HuntleyDivision of Psychiatry, University College London, London, United Kingdom.
Daniel BorDepartment of Psychology, University of Cambridge, Cambridge, United Kingdom.
Feng DengSchool of Psychology, Trinity College Dublin, Global Brain Health Institute, Dublin, Ireland.
Marco MancusoHuman Neuroscience Department, Sapienza University of Rome, Rome, Italy.
Pedro A M MedianoDepartment of Psychology, University of Cambridge, Cambridge, United Kingdom.
Lorina NaciSchool of Psychology, Trinity College Dublin, Global Brain Health Institute, Dublin, Ireland.
Adrian M OwenDepartment of Physiology and Pharmacology, Brain and Mind Institute, University of Western Ontario, London, ON, Canada.
Lorenzo RocchiInstitute of Neurology, University College London, London, United Kingdom.
Avital SterninDepartment of Physiology and Pharmacology, Brain and Mind Institute, University of Western Ontario, London, ON, Canada.
Robert HowardDivision of Psychiatry, University College London, London, United Kingdom.
University College London · GBTrinity College Dublin · IEUniversity of Cambridge · GBWestern University · CASapienza University of Rome · IT

Funding

Wellcome Trust
6 · The paper itself

Abstract

There is an urgent need to understand the nature of awareness in people with severe Alzheimer's disease (AD) to ensure effective person-centered care. Objective biomarkers of awareness validated in other clinical groups (e.g., anesthesia, minimally conscious states) offer an opportunity to investigate awareness in people with severe AD. In this article we demonstrate the feasibility of using Transcranial magnetic stimulation (TMS) combined with EEG, event related potentials (ERPs) and fMRI to assess awareness in severe AD. TMS-EEG was performed in six healthy older controls and three people with severe AD. The perturbational complexity index (PCI

Indexed as

awarenessconsciousnessEEGfMRITMS

Identifiers

PMID36819296
PMCPMC9930987
OpenAlexW4319795032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.