ArticleQuantitative imaging in medicine and surgery2023
Abdominal virtual non-contrast images derived from energy spectrum CT to evaluate chemotherapy-related fatty liver disease.
Article in Quantitative imaging in medicine and surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 4 citations in OpenAlex.
- Study on the combined application of selected virtual monoenergetic imaging, virtual non-contrast imaging, and adaptive statistical iterative reconstruction-V in head and neck CT angiography using 256-slice wide-body CT.Frontiers in medicine · 2026Article
- Dual-layer spectral detector computed tomography-derived virtual non-contrast images in breast cancer patients: a promising alternative to true non-contrast images.Quantitative imaging in medicine and surgery · 2025Article
- Dual-layer spectral detector computed tomography for adrenal adenoma characterization: radiation dose reduction and quantitative agreement of multiphase virtual noncontrast with true noncontrast imaging.Quantitative imaging in medicine and surgery · 2025Article
- Spectral detector computed tomography imaging of histologically confirmed splenic pathologies in 30 canine patients: a comparison of virtual non-contrast images and true unenhanced images.Frontiers in veterinary science · 2025Article
- The ability of virtual noncontrast images to remove intrinsic and external iodine from the thyroid via dual-layer spectral detector computed tomography.Quantitative imaging in medicine and surgery · 2024Article
- Comparison of virtual and true non-contrast images from dual-layer spectral detector computed tomography (CT) in patients with colorectal cancer.Quantitative imaging in medicine and surgery · 2024Article
- Review of the Application of Dual Drug Delivery Nanotheranostic Agents in the Diagnosis and Treatment of Liver Cancer.Molecules (Basel, Switzerland) · 2023Review
- Virtual unenhanced images derived from dual-energy computed tomography for assessing bone mineral density and detecting osteoporosis.Quantitative imaging in medicine and surgery · 2023Article
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10 authors at 2 institutions in 1 country.
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Abstract
Background: Chemotherapy-related fatty liver disease (CRFLD) is an important evaluation in patients undergoing computed tomography (CT) for cancer follow-up. This study set out to explore the feasibility of using abdominal virtual non-contrast (VNC) images derived from energy spectrum CT to evaluate CRFLD and reduce the radiation dose. Methods: A total of 160 eligible consecutive patients who underwent energy spectrum CT at Lanzhou University Second Hospital between June 2020 and July 2021 were retrospectively enrolled. The average CT attenuation values of the liver and spleen and the liver-to-spleen ratio (LSR) were measured by two independent blinded radiologists on true non-contrast (TNC) images and three types of VNC image. The diagnostic performance of the LSR for CRFLD, image quality, and diagnostic confidence were compared between the two types of imaging. Results: The average CT attenuation values of the liver and spleen were significantly lower on VNC images than on TNC images (P<0.05), whereas the LSR showed good agreement between the two (P>0.05). The average CT attenuation values of the liver and the LSR measured on the TNC and three types of VNC image were significantly lower in patients with CRFLD than in those without CRFLD (P<0.001). The area under the curve (AUC) values of the LSR for the diagnosis of CRFLD calculated on TNC and three types of VNC image were 0.870 (95% CI: 0.808-0.918), 0.852 (95% CI: 0.787-0.903), 0.819 (95% CI: 0.750-0.875), and 0.851 (95% CI: 0.786-0.902), respectively. The DeLong test confirmed the consistency of TNC and VNC images of diagnostic efficacy (P>0.05). There were no significant differences in image quality or diagnostic confidence between the TNC and three types of VNC image (P>0.05). When VNC imaging was applied, the radiation dose was reduced by approximately 25.0%. Conclusions: VNC imaging could become a reliable alternative to TNC imaging for the clinical evaluation of patients with CRFLD and could reduce the radiation dose by up to 25%.
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