Evidence map›Paper›PMID 36819146›Full record

ArticleEJHaem2023

Real-world use of carfilzomib combined with lenalidomide and dexamethasone in patients with multiple myeloma in Europe and Israel.

Xavier Leleu, Eirini Katodritou, Thomas Kuehr, Evangelos Terpos, Jo Caers, Renato Zambello, Alessandra Brescianini, Tony Liang, Sally Wetten, Sorina N Badelita

Registry-linked trialOpen access · diamondAbstract read
In one paragraph

Article in EJHaem, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03091127 (Real-world Use of Carfilzomib Among Multiple Myeloma Patients in Europe Who Have Received at Least One Prior Therapy.), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03091127 completednot on this map

Real-world Use of Carfilzomib Among Multiple Myeloma Patients in Europe Who Have Received at Least One Prior Therapy.

TypeobservationalSponsorAmgenRan2017 to 2020Enrolled705ConditionsMultiple Myeloma
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 10 institutions in 8 countries.

Xavier LeleuDepartment of Haematology University Hospital Centre La Miletrie and Inserm Poitiers France.ORCID https://orcid.org/0000-0002-9822-4170
Eirini KatodritouDepartment of Haematology Theagenio Cancer Hospital Thessaloniki Greece.ORCID https://orcid.org/0000-0001-9404-807X
Thomas KuehrDepartment of Internal Medicine IV Academic Teaching Hospital Wels-Grieskirchen Wels Austria.
Evangelos TerposDepartment of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens Athens Greece.ORCID https://orcid.org/0000-0001-5133-1422
Jo CaersDepartment of Haematology Liège University Hospital Centre Liège Belgium.ORCID https://orcid.org/0000-0002-3175-1195
Renato ZambelloDepartment of Medicine Haematology and Clinical Immunology Branch, University of Padua Padua Italy.ORCID https://orcid.org/0000-0002-8799-5324
Alessandra BrescianiniResearch and Development Department Amgen (Europe) GmbH Rotkreuz Switzerland.
Tony LiangDepartment of Biostatistics Parexel International Taipei Taiwan.
Sally WettenCenter for Observational Research Amgen Ltd Uxbridge UK.
Sorina N BadelitaDepartment of Hematology Fundeni Clinical Institute Bucharest Romania.ORCID https://orcid.org/0000-0002-1507-2547
Amgen (Switzerland) · CHAmgen (United Kingdom) · GBCentre Hospitalier Universitaire de Liège · BEInserm · FRInstitutul Clinic Fundeni · ROKlinikum Wels-Grieskirchen · ATNational and Kapodistrian University of Athens · GRPAREXEL International (United Kingdom) · GBTheageneio General Hospital · GRUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical trials have demonstrated the efficacy and safety of carfilzomib in patients with relapsed/refractory multiple myeloma (RRMM); however, prospective real-world data are limited. This real-world, prospective, observational study evaluated carfilzomib use, effectiveness and safety in adults with RRMM. Data are presented for a subset of patients (

Indexed as

carfilzomibmultiple myelomaproteasome inhibitorreal worldrelapsed/refractory

Identifiers

PMID36819146
PMCPMC9928790
OpenAlexW4308320802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.