Evidence map›Paper›PMID 36819134›Full record

ArticleJournal of medical biochemistry2023

Pregnancy outcomes and newborn characteristics in women with follicular fluid thyroid autoantibodies undergoing assisted reproduction.

Sanja Medenica, Eliana Garalejić, Džihan Abazović, Zoran Bukumirić, Stavroula A Paschou, Biljana Arsić, Snežana Vujošević, Biljana Međo, Miloš Žarković

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Sanja MedenicaUniversity of Montenegro, School of Medicine, Clinical Center of Montenegro, Internal Medicine Clinic, Department of Endocrinology, Podgorica, Montenegro.
Eliana GaralejićClinic for Gynecology and Obstetrics "Narodni front", In Vitro Fertilisation Department, Belgrade.
Džihan AbazovićEmergency Medicine Center of Montenegro, Podgorica, Montenegro.
Zoran BukumirićUniversity of Belgrade, Institute for Medical Statistics and Informatics, Faculty of Medicine, Belgrade.
Stavroula A PaschouNational and Kapodistrian University of Athens, School of Medicine, Alexandra Hospital, Endocrine Unit and Diabetes Centre, Department of Clinical Therapeutics, Athens, Greece.
Biljana ArsićClinic for Gynecology and Obstetrics "Narodni front", In Vitro Fertilisation Department, Belgrade.
Snežana VujoševićUniversity of Montenegro, School of Medicine, Clinical Center of Montenegro, Internal Medicine Clinic, Department of Endocrinology, Podgorica, Montenegro.
Biljana MeđoUniversity of Belgrade, School of Medicine, Belgrade.
Miloš ŽarkovićUniversity of Belgrade, School of Medicine, Belgrade.
University of Belgrade · RSUniversity of Montenegro · MENational and Kapodistrian University of Athens · GRSoil and Fertilizer Institute of Hunan Province · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Higher levels of thyroid autoantibodies in follicular fluid (FF) of thyroid autoimmunity (TAI) positive women are strongly correlated with serum levels and may have effect on the post-implantation embryo development. Literature highlights that levothyroxine (LT4) treatment may attenuate the risk of adverse pregnancy outcomes. The aim of the study was to estimate the pregnancy and newborn outcomes in women with FF thyroid autoantibodies undergoing assisted reproductive technology (ART). Methods: The study population included 24 women with confirmed clinical pregnancy, 8 TAI positive and 16 TAI negative women. LT4 supplementation was applied in 20.8% patients, TAI positive. Results: Pregnancy outcomes were: twin pregnancy rate 41.7%, early miscarriage rate 8.3%, late miscarriage rate 4.2%, preterm birth rate 16.7%, term birth rate 70.8%, live birth rate 96.0%. There was significant difference in serum and in FF TgAbs (p< 0.001)between the groups according to TAI, while serum fT Conclusions: Thyroid autoantibodies present in FF may have an effect on the post-implantation embryo development, but have no effect on further course of pregnancy. The special benefit of LT4 treatment for successful ART outcome was demonstrated for newborn anthropometric parameters.

Indexed as

assisted reproductive technologyfollicular fluidpregnancythyroid autoimmunity

Identifiers

PMID36819134
PMCPMC9920930
OpenAlexW4283693515

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.