Evidence map›Paper›PMID 36819069›Full record

ReviewFrontiers in microbiology2023

Interrogating the role of the milk microbiome in mastitis in the multi-omics era.

Sneha P Couvillion, Katie E Mostoller, Janet E Williams, Ryan M Pace, Izabel L Stohel, Haley K Peterson, Carrie D Nicora, Ernesto S Nakayasu, Bobbie-Jo M Webb-Robertson, Mark A McGuire and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Sneha P CouvillionPacific Northwest National Laboratory, Earth and Biological Sciences Directorate, Richland, WA, United States.
Katie E MostollerPacific Northwest National Laboratory, Earth and Biological Sciences Directorate, Richland, WA, United States.
Janet E WilliamsDepartment of Animal, Veterinary, and Food Sciences, University of Idaho, Moscow, ID, United States.
Ryan M PaceMargaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, ID, United States.
Izabel L StohelPacific Northwest National Laboratory, Earth and Biological Sciences Directorate, Richland, WA, United States.
Haley K PetersonDepartment of Animal, Veterinary, and Food Sciences, University of Idaho, Moscow, ID, United States.
Carrie D NicoraPacific Northwest National Laboratory, Earth and Biological Sciences Directorate, Richland, WA, United States.
Ernesto S NakayasuPacific Northwest National Laboratory, Earth and Biological Sciences Directorate, Richland, WA, United States.
Bobbie-Jo M Webb-RobertsonPacific Northwest National Laboratory, Earth and Biological Sciences Directorate, Richland, WA, United States.
Mark A McGuireDepartment of Animal, Veterinary, and Food Sciences, University of Idaho, Moscow, ID, United States.
Michelle K McGuireMargaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, ID, United States.
Thomas O MetzPacific Northwest National Laboratory, Earth and Biological Sciences Directorate, Richland, WA, United States.
Pacific Northwest National Laboratory · USUniversity of Idaho · US

Funding

Mammary and milk microbiomes and metabolomes - Understanding early variation and impacts on risk for mammary inflammation and mastitisR01HD092297 · NICHD · UNIVERSITY OF IDAHO · PI MCGUIRE, MICHELLE KAY · 2018 to 2022
$2.4M
NICHD NIH HHS R01 HD092297
6 · The paper itself

Abstract

There is growing interest in a functional understanding of milk-associated microbiota as there is ample evidence that host-associated microbial communities play an active role in host health and phenotype. Mastitis, characterized by painful inflammation of the mammary gland, is prevalent among lactating humans and agricultural animals and is associated with significant clinical and economic consequences. The etiology of mastitis is complex and polymicrobial and correlative studies have indicated alterations in milk microbial community composition. Recent evidence is beginning to suggest that a causal relationship may exist between the milk microbiota and host phenotype in mastitis. Multi-omic approaches can be leveraged to gain a mechanistic, molecular level understanding of how the milk microbiome might modulate host physiology, thereby informing strategies to prevent and ameliorate mastitis. In this paper, we review existing studies that have utilized omics approaches to investigate the role of the milk microbiome in mastitis. We also summarize the strengths and challenges associated with the different omics techniques including metagenomics, metatranscriptomics, metaproteomics, metabolomics and lipidomics and provide perspective on the integration of multiple omics technologies for a better functional understanding of the milk microbiome.

Indexed as

lipidomicsmastitismetabolomicsmetagenomicsmetaproteomicsmetatranscriptomicsmilkmulti-omics

Identifiers

PMID36819069
PMCPMC9932517
OpenAlexW4319020474

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.