ReviewFrontiers in microbiology2023
Enhancing chemical and biological diversity by co-cultivation.
Review in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Different co-culture approaches to increase metabolites in foods.Food science and biotechnology · 2026Review
- Pigmented fungi derived from hot and cold deserts ecosystems: taxonomy, genomic and biotechnological approach.World journal of microbiology & biotechnology · 2026Review
- Advancing microalgae biomass cultivation for an integrated sustainable wastewater treatment and resource recovery.iScience · 2026Review
- Species-specific glucose mineralization in artificial soil: insights fromMicrobiology spectrum · 2026Article
- Fungal-Bacterial Interactions in Polymicrobial Infections: Hidden Threats.MicrobiologyOpen · 2026Review
- Biocalorimetry for the biotechnological use of natural and synthetic macromolecules.Applied microbiology and biotechnology · 2026Review
- Engineering a Compartmentalized Multi-Cell Co-Culture Hydrogel System Using Beeswax/Fucoidan/Alginate for Cultured Meat Modeling.Foods (Basel, Switzerland) · 2026Article
- Changes in the enzyme profile of the white-rot fungus Bjerkandera adusta in co-culture with the brown-rot fungus Gloeophyllum trabeum and its potential for dye decolorization.World journal of microbiology & biotechnology · 2026Article
- Co-cultivation dynamics of the filamentous microorganisms Aspergillus niger and Streptomyces coelicolor in shake flasks.Microbial cell factories · 2026Article
- From Contact to Stalemate: MAPK-Associated Chemical and Enzymatic Defenses Shape a Stable Barrage in the Co-Culture ofJournal of fungi (Basel, Switzerland) · 2026Article
- Genetic Dereplication of MultipleJournal of natural products · 2026Article
- Desferrioxamine Sharing among Microalgae-Associated Bacteria Enhances Iron-Limited Inhibition ofJournal of natural products · 2026Article
- Harnessing engineered cyanobacteria for next-generation therapeutics.Archives of microbiology · 2026Review
- Unlocking the potential of endophytes in enhancing plant secondary metabolite biosynthesis.Biochemistry and biophysics reports · 2026Review
- Generation of Novel Natural Products by Disrupting Azaphilone Synthesis inMarine drugs · 2026Article
- Valorisation of spent mushroom substrate by secondary microbial fermentation.Applied microbiology and biotechnology · 2026Review
- Differential modulation of α-pyrone production in co-cultures of Pestalotiopsis diospyri with three phytopathogenic fungi.Archives of microbiology · 2026Article
- Bactericidal and antibiofilm activity of lactic acid bacteria-derived cell free extracts against dairy-associated spoilage and pathogenic bacteria.Frontiers in microbiology · 2026Article
- Mixed-microbe solid-state fermentation modulates the physicochemical and aroma profiles ofFrontiers in microbiology · 2026Article
- Mathematical Modeling ofInternational journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In natural product research, microbial metabolites have tremendous potential to provide new therapeutic agents since extremely diverse chemical structures can be found in the nearly infinite microbial population. Conventionally, these specialized metabolites are screened by single-strain cultures. However, owing to the lack of biotic and abiotic interactions in monocultures, the growth conditions are significantly different from those encountered in a natural environment and result in less diversity and the frequent re-isolation of known compounds. In the last decade, several methods have been developed to eventually understand the physiological conditions under which cryptic microbial genes are activated in an attempt to stimulate their biosynthesis and elicit the production of hitherto unexpressed chemical diversity. Among those, co-cultivation is one of the most efficient ways to induce silenced pathways, mimicking the competitive microbial environment for the production and holistic regulation of metabolites, and has become a golden methodology for metabolome expansion. It does not require previous knowledge of the signaling mechanism and genome nor any special equipment for cultivation and data interpretation. Several reviews have shown the potential of co-cultivation to produce new biologically active leads. However, only a few studies have detailed experimental, analytical, and microbiological strategies for efficiently inducing bioactive molecules by co-culture. Therefore, we reviewed studies applying co-culture to induce secondary metabolite pathways to provide insights into experimental variables compatible with high-throughput analytical procedures. Mixed-fermentation publications from 1978 to 2022 were assessed regarding types of co-culture set-ups, metabolic induction, and interaction effects.
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