ArticleFrontiers in microbiology2023
A genome-wide cross-cancer meta-analysis highlights the shared genetic links of five solid cancers.
Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 9 citations in OpenAlex.
- Large-scale pleiotropic analysis across cancers reveals shared genetic mechanisms and identifies novel functional genes.Briefings in bioinformatics · 2026Article
- Opinions on the effect of alcohol on cancer risk among US adults in 2024.Cancer causes & control : CCC · 2026Article
- Cross-ancestral GWAS identifies 29 variants across head and neck cancer subsites.Nature communications · 2025Article
- The contribution of coding variants to the heritability of multiple cancer types using UK Biobank whole-exome sequencing data.American journal of human genetics · 2025Article
- rs2736098, a synonymous polymorphism, is associated with carcinogenesis and cell count in multiple tissue types by regulatingHeliyon · 2024Article
- Investigation of common genetic risk factors between thyroid traits and breast cancer.Human molecular genetics · 2023Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
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Abstract
Breast, ovarian, prostate, lung, and head/neck cancers are five solid cancers with complex interrelationships. However, the shared genetic factors of the five cancers were often revealed either by the combination of individual genome-wide association study (GWAS) approach or by the fixed-effect model-based meta-analysis approach with practically impossible assumptions. Here, we presented a random-effect model-based cross-cancer meta-analysis framework for identifying the genetic variants jointly influencing the five solid cancers. A comprehensive genetic correlation analysis (genome-wide, partitioned, and local) approach was performed by using GWAS summary statistics of the five cancers, and we observed three cancer pairs with significant genetic correlation: breast-ovarian cancer (
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