ArticleFrontiers in plant science2023
Integrated transcriptome and metabolome analysis reveals that flavonoids function in wheat resistance to powdery mildew.
Article in Frontiers in plant science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Synergistic and Fungicide-Reducing Effects of Biological Agents with Chemical Fungicides against Ginseng Rusty Root Rot.Journal of agricultural and food chemistry · 2026Article
- Genomics assisted breeding for mildew resistance in cucumber: from gene discovery to future innovations.Plant molecular biology · 2026Review
- Deciphering the Biosynthetic Pathways and Regulatory Networks of the Active Components ofInternational journal of molecular sciences · 2026Article
- A Comparison of the Occurrence of Bioactive Compounds in the Grain of DifferentMolecules (Basel, Switzerland) · 2026Review
- VvERF105 enhances drought resistance in grape through interaction with VvSnRK1.Frontiers in plant science · 2026Article
- Integrated transcriptomic and metabolomic analysis reveals the central role of phenylpropanoid biosynthesis in pea resistance to powdery mildew.Frontiers in plant science · 2026Article
- Review
- Untargeted metabolomics and functional analyses reveal that the secondary metabolite quinic acid associates with Angelica sinensis flowering.BMC plant biology · 2025Article
- Article
- Integrated metabolome-transcriptome analyses reveal key pathways regulating staminate catkin development and pollen maturation inFrontiers in plant science · 2025Article
- Integrated transcriptome and metabolome analyses reveals the mechanisms of function loss ofFrontiers in plant science · 2025Article
- Multi-Omics Analysis Provides Insights into Green Soybean in Response to Cold Stress.Metabolites · 2024Article
- Yield, cell structure and physiological and biochemical characteristics of rapeseed under waterlogging stress.BMC plant biology · 2024Article
- Combined metabolome and transcriptome reveal HmF6'H1 regulating simple coumarin accumulation against powdery mildew infection in Heracleum moellendorffii Hance.BMC plant biology · 2024Article
- Article
- Exogenous Calcium Alleviates Oxidative Stress Caused by Salt Stress in Peanut Seedling Roots by Regulating the Antioxidant Enzyme System and Flavonoid Biosynthesis.Antioxidants (Basel, Switzerland) · 2024Article
- Reduction of flavonoid content in honeysuckle viaFrontiers in plant science · 2024Article
- Integrating transcriptomics and metabolomics to analyze the defense response ofFrontiers in microbiology · 2024Article
- Responses of transcriptome and metabolome in peanut leaves to dibutyl phthalate during whole growth period.Frontiers in plant science · 2024Article
- Comparative transcriptome and metabolome analysis revealed diversity in the response of resistant and susceptible rose (Frontiers in plant science · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Powdery mildew is a fungal disease devastating to wheat, causing significant quality and yield loss. Flavonoids are important secondary plant metabolites that confer resistance to biotic and abiotic stress. However, whether they play a role in powdery mildew resistance in wheat has yet to be explored. In the present study, we combined transcriptome and metabolome analyses to compare differentially expressed genes (DEGs) and differentially accumulated flavonoids identified in plants with and without powdery mildew inoculation. Transcriptome analysis identified 4,329 DEGs in susceptible wheat cv. Jimai229, and 8,493 in resistant cv. HHG46. The DEGs were functionally enriched using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes, revealing the flavonoid synthesis pathway as the most significant in both cultivars. This was consistent with the upregulation of flavonoid synthesis pathway genes observed by quantitative PCR. Metabolome analysis indicated flavone and flavonol biosynthesis pathways as the most significantly enriched following powdery mildew inoculation. An accumulation of total flavonoids content was also found to be induced by powdery mildew infection. Exogenous flavonoids treatment of inoculated plants led to less severe infection, with fewer and smaller powdery mildew spots on the wheat leaves. This reduction is speculated to be regulated through malondialdehyde content and the activities of peroxidase and catalase. Our study provides a fundamental theory for further exploration of the potential of flavonoids as biological prevention and control agents against powdery mildew in wheat.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.