ArticleFrontiers in plant science2023
Integrative analysis of transcriptome and metabolome revealed the mechanisms by which flavonoids and phytohormones regulated the adaptation of alfalfa roots to NaCl stress.
Article in Frontiers in plant science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 39 citations in OpenAlex.
- Functional analysis ofPlant signaling & behavior · 2026Article
- Physiological and molecular mechanisms of Medicago ruthenica in response to different saline-alkali stresses.BMC plant biology · 2026Article
- Deciphering the Biosynthetic Pathways and Regulatory Networks of the Active Components ofInternational journal of molecular sciences · 2026Article
- Integrated morphological, physiological, and transcriptomic profiling unveils a root-centric defense network mediating aluminum tolerance in Trifolium repens L.BMC plant biology · 2026Article
- Temporal Transcriptomic and Metabolomic Reprogramming Unveils a Two-Phase Salt Tolerance Mechanism inInternational journal of molecular sciences · 2026Article
- Metabolo-Transcriptomics Analyses Reveal Alfalfa Adaptation to Combined Saline-Alkali and Low-Temperature Stress in the Field.Plant biotechnology journal · 2026Article
- Flavonoids in Plant Salt Stress Responses: Biosynthesis, Regulation, Functions, and Signaling Networks.Plants (Basel, Switzerland) · 2026Review
- Mechanistic insights and breeding prospects of secondary metabolites in wheat salt stress tolerance.Planta · 2026Review
- Drought-salinity interaction suppresses seed germination and seedling growth in alfalfa by altering water status, membrane stability, and antioxidant responses.Frontiers in plant science · 2026Article
- The lignin deposition responses of different poplar root systems to salt stress.Frontiers in plant science · 2026Article
- Effects of moisture-preserving yellowing process optimization on cell physiology and post-curing chemical composition.BMC plant biology · 2025Article
- Metabolic Characteristics of PGPR-Induced Growth Promotion in Alfalfa (Metabolites · 2025Article
- Root Transcriptome Analysis Identifies Salt-Tolerance Genes in Sweet Corn Chromosome Segment Substitution Lines (CSSLs).Plants (Basel, Switzerland) · 2025Article
- Transcriptomic analysis of melatonin-mediated drought stress response genes in alfalfa during germination period.BMC plant biology · 2025Article
- Molecular Mechanisms of Alfalfa Response to Abiotic Stresses.Plants (Basel, Switzerland) · 2025Review
- Integrative omics analysis of plant-microbe synergies in petroleum pollution remediation.PeerJ · 2025Article
- Salt gradient-driven adaptation in okra: uncovering mechanisms of tolerance and growth regulation.Frontiers in plant science · 2025Article
- Thriving in a salty future: morpho-anatomical, physiological and molecular adaptations to salt stress in alfalfa (Medicago sativa L.) and other crops.Annals of botany · 2024Review
- Exogenous Calcium Enhances Castor Tolerance to Saline-Alkaline Stress by Regulating Antioxidant Enzyme Activity and Activating CaInternational journal of molecular sciences · 2024Article
- Understanding of Plant Salt Tolerance Mechanisms and Application to Molecular Breeding.International journal of molecular sciences · 2024Review
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Introduction: Salinity critically affects the growth and development of alfalfa (Medicago sativa), making it necessary to understand the molecular mechanism of alfalfa's adaptation to salt stress. Methods: In this study, alfalfa roots were subjected to salt stress and transcriptomics and metabolomics analyses were performed. Results: The results showed that flavonoid synthesis, hormone synthesis, and transduction pathways may be involved in the alfalfa salt stress adaptation reaction, and that they are related. Combined analysis of differential genes and differential metabolites found that dihydroquercetin and beta-ring hydroxylase (LUT5), ABA responsive element binding factor 2 (ABF2), protein phosphatase PP2C (PP2C) and abscisic acid (ABA) receptor PYL2 (PYL), luteolinidin was significantly correlated with PP2C and phytochrome-interacting factor 4 (PIF4) and (+)-7-isomethyl jasmonate were significantly correlated with flavonol synthase (FLS) gene. (+)-7-isomethyl jasmonate and homoeriodictyol chalcone were significantly correlated with peroxidase (POD). POD was significantly up-regulated under NaCl stress for 6 and 24 h. Moreover, flavonoids, gibberellin (GA), jasmonic acid (JA) and ABA were suggested to play an important role in alfalfa's response to salt stress. Further, GA,ABA, and JA may be involved in the regulation of flavonoids to improve alfalfa's salt tolerance, and JA may be a key signal to promote the synthesis of flavonoids. Discussion: This study revealed the possible molecular mechanism of alfalfa adaptation to salt stress, and identified a number of salt-tolerance candidate genes from the synthesis and signal transduction pathways of flavonoids and plant hormones, providing new insights into the regulatory network of alfalfa response to salt stress.
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