Evidence map›Paper›PMID 36818804›Full record

ArticleInternational journal of endocrinology2023

Levothyroxine Timing during Ramadan: A Randomized Clinical Trial.

Moeber Mahzari, Fahad Al Remthi, Ibrahim Ajwah, Mohammed Al Hazmi, Wesam Moafa, Awad Al Shahrani, Sameerah Al Shehri, Motasim Badri

Open access · goldAbstract read
In one paragraph

Article in International journal of endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Moeber MahzariCollege of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0002-6796-9428
Fahad Al RemthiKing Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Ibrahim AjwahKing Abdullah International Medical Research Center, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0001-7518-632X
Mohammed Al HazmiKing Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Wesam MoafaKing Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Awad Al ShahraniCollege of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0001-8266-6145
Sameerah Al ShehriCollege of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0003-4226-5894
Motasim BadriKing Abdullah International Medical Research Center, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0002-5268-6492
King Abdullah International Medical Research Center · SAKing Saud bin Abdulaziz University for Health Sciences · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hypothyroidism requires lifelong thyroid hormone replacement with levothyroxine. For most hypothyroid patients fasting during Ramadan, compliance with the administration procedure is a challenge. This study aimed to determine the impact of different administration times of levothyroxine on thyroid-stimulating hormone (TSH) and free T4 (FT4) levels before and after the holy month of Ramadan. Results: Compliance was lower in patients taking levothyroxine 3-4 hours after iftar. In addition, the majority of patients who had not received a specific recommendation took levothyroxine 30 minutes before iftar. There was a statistically significant increase in TSH ( Conclusion: TSH and FT4 significantly increased after Ramadan. However, the timing of levothyroxine intake per se had no influence on TSH or free T4 levels. Therefore, hypothyroid patients might take levothyroxine either 30 minutes or 3-4 hours after iftar with no meal for 1 hour, depending on preference.

Identifiers

PMID36818804
PMCPMC9937748
OpenAlexW4319879832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.