Evidence map›Paper›PMID 36818675›Full record

ReviewFrontiers in oncology2022

Rechallenge with anti-EGFR therapy to extend the continuum of care in patients with metastatic colorectal cancer.

Chiara Cremolini, Clara Montagut, Philippe Ronga, Filippo Venturini, Kensei Yamaguchi, Sebastian Stintzing, Alberto Sobrero

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Expert consensus on the optimal management of BRAFAsia-Pacific journal of clinical oncology · 2025
    Article
  6. Article
  7. Review
  8. Observational
  9. Article
  10. Review
  11. The ideal reporting ofPathologica · 2023
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 4 countries.

Chiara CremoliniUnit of Medical Oncology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Clara MontagutDepartment of Medical Oncology, Hospital del Mar- Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Barcelona, Spain.
Philippe RongaGlobal Medical Affairs, Merck Healthcare KGaA, Darmstadt, Germany.
Filippo VenturiniGlobal Medical Affairs, Merck Serono S.p.A., an Affiliate of Merck KGaA, Rome, Italy.
Kensei YamaguchiDepartment of Gastroenterological Chemotherapy, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
Sebastian StintzingDepartment of Hematology, Oncology, and Cancer Immunology (CCM), Charité-Universitätsmedizin, Berlin, Germany.
Alberto SobreroDepartment of Medical Oncology, Ospedale San Martino, Genoa, Italy.
Charité - Universitätsmedizin Berlin · DEHospital del Mar Research Institute · ESJapanese Foundation For Cancer Research · JPMerck (Germany) · DEMerck Serono (Italy) · ITOspedale Policlinico San Martino · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with

Indexed as

anti-EGFRliquid biopsymetastatic colorectal cancer (mCRC)rechallengereintroduction

Identifiers

PMID36818675
PMCPMC9932317
OpenAlexW4319023497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.