Evidence map›Paper›PMID 36818571›Full record

ArticleAging and disease2023

A Reliable Nonhuman Primate Model of Ischemic Stroke with Reproducible Infarct Size and Long-term Sensorimotor Deficits.

Xiao Lin, Hua Wang, Shengwei Huang, Lefu Chen, Su Yang, Peiqi Zhao, Zhongxiao Lin, Jianjing Yang, Linhui Ruan, Haoqi Ni and 4 more

Open access · goldAbstract read
In one paragraph

Article in Aging and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Xiao Lin1Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Hua Wang1Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Shengwei Huang1Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Lefu Chen1Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Su Yang2Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, Wenzhou Medical University, Wenzhou, China.
Peiqi Zhao1Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Zhongxiao Lin1Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jianjing Yang1Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Linhui Ruan1Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Haoqi Ni1Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Kankai Wang1Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Min Wen3Department of Neurology, Guangzhou First People's Hospital, Guangzhou, China.
Kunlin Jin4Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Qichuan Zhuge1Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
First Affiliated Hospital of Wenzhou Medical University · CNWenzhou Medical University · CNUniversity of North Texas · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A nonhuman primate model of ischemic stroke is considered as an ideal preclinical model to replicate various aspects of human stroke because of their similarity to humans in genetics, neuroanatomy, physiology, and immunology. However, it remains challenging to produce a reliable and reproducible stroke model in nonhuman primates due to high mortality and variable outcomes. Here, we developed a focal cerebral ischemic model induced by topical application of 50% ferric chloride (FeCl

Indexed as

cynomolgus macaqueferric chlorideischemic strokemiddle cerebral arterynonhuman primate

Identifiers

PMID36818571
PMCPMC9937702
OpenAlexW4312401770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.