Evidence map›Paper›PMID 36818558›Full record

ArticleAging and disease2023

Epidural Pulsation Accelerates the Drainage of Brain Interstitial Fluid.

Xianjie Cai, Qingyuan He, Wei Wang, Chunlin Li, Hui Wang, Feng Yin, Tong Li, Dongsheng Kong, Yanxing Jia, Hongfeng Li and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

Xianjie Cai1Institute of Medical Technology, Peking University Health Science Center, Beijing, China.
Qingyuan He2Department of Radiology, Peking University Third Hospital, Beijing, China.
Wei Wang4Department of Radiology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China.
Chunlin Li5School of Biomedical Engineering, Capital Medical University, Beijing, China.
Hui Wang1Institute of Medical Technology, Peking University Health Science Center, Beijing, China.
Feng Yin6Department of Neurosurgery, Aerospace Center Hospital, Peking University Aerospace Clinical College, Beijing, China.
Tong Li6Department of Neurosurgery, Aerospace Center Hospital, Peking University Aerospace Clinical College, Beijing, China.
Dongsheng Kong7Department of Neurosurgery, First Medical Center, General Hospital of Chinese PLA, Beijing, China.
Yanxing Jia8State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Hongfeng Li1Institute of Medical Technology, Peking University Health Science Center, Beijing, China.
Junhao Yan9Department of Anatomy and Histology, School of Basic Medical Sciences, Peking University, Beijing, China.
Xunbin Wei1Institute of Medical Technology, Peking University Health Science Center, Beijing, China.
Qiushi Ren1Institute of Medical Technology, Peking University Health Science Center, Beijing, China.
Yajuan Gao2Department of Radiology, Peking University Third Hospital, Beijing, China.
Shuangfeng Yang11Department of Radiology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Huaiyu Tong7Department of Neurosurgery, First Medical Center, General Hospital of Chinese PLA, Beijing, China.
Yun Peng11Department of Radiology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Hongbin Han1Institute of Medical Technology, Peking University Health Science Center, Beijing, China.
Peking University · CNCapital Medical University · CNChinese PLA General Hospital · CNPeking University Third Hospital · CNBeijing Children’s Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unhindered transportation of substances in the brain extracellular space (ECS) is essential for maintaining brain function. Regulation of transportation is a novel strategy for treating ECS blockage-related brain diseases, but few techniques have been developed to date. In this study, we established a novel approach for accelerating the drainage of brain interstitial fluid (ISF) in the ECS using minimally invasive surgery, in which a branch of the external carotid artery is separated and implanted epidurally (i.e., epidural arterial implantation [EAI]) to promote a pulsation effect on cerebrospinal fluid (CSF) in the frontoparietal region. Tracer-based magnetic resonance imaging was used to evaluate the changes in ISF drainage in rats 7 and 15 days post-EAI. The drainage of the traced ISF from the caudate nucleus to ipsilateral cortex was significantly accelerated by EAI. Significant increases in the volume fraction of the ECS and molecular diffusion rate were demonstrated using the D

Indexed as

braincerebrospinal fluidextracellular spaceinterstitial fluidMRI

Identifiers

PMID36818558
PMCPMC9937704
OpenAlexW4312446712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.