ArticleFrontiers in cardiovascular medicine2023
Red cell distribution width (RDW) is correlated to time of oxygen desaturation < 90% and length of sleep apneas in patients with sleep disorder breathing (SDB) and acute heart failure with preserved ejection fraction (HFpEF).
Article in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Erythrocyte and Platelet Indices at Admission and Discharge Stratify Long-Term Cardiovascular Risk After Invasive Treatment of Myocardial Infarction.Journal of clinical medicine · 2026Article
- Impact of red cell distribution width in school-age children with congenital heart disease.Heart and vessels · 2026Article
- The association of complete blood count parameters and obstructive sleep apnea in the Cypriot population.Sleep & breathing = Schlaf & Atmung · 2025Article
- Correlation of mean platelet volume and red blood cell distribution width with obstructive sleep apnoea syndrome severity.Lung India : official organ of Indian Chest Society · 2025Article
- Prognostic Value of the Red Cell Distribution Width-to-eGFR Ratio (RGR) Across Chronic Heart Failure Phenotypes: A Retrospective Observational Pilot Study.Journal of clinical medicine · 2025Article
- Red blood cell distribution width to albumin ratio is correlated with prognosis of patients in coronary care unit.World journal of cardiology · 2025Article
- Association between RDW-to-albumin ratio and mortality in HFpEF: a retrospective study based on MIMIC-IV and external validation.Frontiers in nutrition · 2025Article
- Insights into the Interaction of Heart Failure with Preserved Ejection Fraction and Sleep-Disordered Breathing.Biomedicines · 2023Review
- Association between Red Blood Cell Distribution Width and Obstructive Sleep Apnea Syndrome: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
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Authors and funding
8 authors at 4 institutions in 1 country.
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Abstract
Background: Heart failure with preserved ejection fraction (HFpEF) is very frequently associated to sleep breathing disorders (SDB). Red blood cell distribution width (RDW) has been shown to be a potential inflammatory index linked to the degree of hypoxia and oxidative stress. Aim: To identify the existence of a possible relationship between sleep apnea, oxygen saturation (SaO2) and RDW in a population of subjects affected by acute HFpEF (AHFpEF). Methods: AHFpEF patients with known history of SDB were enrolled and performed blood chemistry, echocardiography, and 24-h polysomnography (PSG). Results: A total of 34 acute HFpEF patients (mean age 72.8 +/-8.63) were enrolled in the study. A control group of 24 non-HF patients were considered. Compared to controls, HFpEF patients showed a higher mean apnea hypopnea index (AHI), with prevalence of central apneas. A moderate to severe desaturation pattern was observed in AHFpEF vs. controls. RDW was significantly higher in AHFpEF patients vs. controls (mean value 14.7 +/-2.6 % vs. 9.1 +/-2.2, Conclusion: In patients with AHFpEF and SDB, a dependence relationship between RDW and duration of oxygen desaturation was observed, as if oxidative stress and inflammation related to RDW increase could also be linked to severity of sleep disorders in this population.
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