Evidence map›Paper›PMID 36818013›Full record

ArticleJournal of biomedical physics & engineering2023

Exposure to Low Levels of Radiofrequency Electromagnetic Fields Emitted from Cell-phones as a Promising Treatment of Alzheimer's Disease: A Scoping Review Study.

Kiarash Shirbandi, Mohammad Khalafi, Joseph J Bevelacqua, Najmeh Sadeghian, Saina Adiban, Faegheh Bahaeddini Zarandi, Seyed Alireza Mortazavi, Seyedeh Haniyeh Mortazavi, Seyed Mohammad Javad Mortazavi, James S Welsh

Open access · goldAbstract readScoping Review
In one paragraph

Article in Journal of biomedical physics & engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Kiarash ShirbandiDepartment of International Affairs (IAD), Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Mohammad KhalafiAllied Health Science, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Joseph J BevelacquaBevelacqua Resources, Richland, Washington 99352, United States.
Najmeh SadeghianStudent Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Saina AdibanBiotechnology Student, Islamic Azad University, Tehran, Iran.
Faegheh Bahaeddini ZarandiDepartment of Pharmacology, School of Medicine, Shiraz University of Medical Sciencs, Shiraz, Iran.
Seyed Alireza MortazaviSchool of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyedeh Haniyeh MortazaviSchool of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyed Mohammad Javad MortazaviDepartment of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
James S WelshDepartment of Radiation Oncology, Stritch School of Medicine, Loyola University, Chicago, IL, USA.
Shiraz University of Medical Sciences · IRAhvaz Jundishapur University of Medical Sciences · IREdward Hines, Jr. VA Hospital · USIslamic Azad University, Tehran · IRMazandaran University of Medical Sciences · IRTabriz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Alzheimer's disease (AD) is one of the most significant public health concerns and tremendous economic challenges. Studies conducted over the past decades show that exposure to radiofrequency electromagnetic fields (RF-EMFs) may relieve AD symptoms. Objective: To determine if exposure to RF-EMFs emitted by cellphones affect the risk of AD. Material and Methods: In this review, all relevant published articles reporting an association of cell phone use with AD were studied. We systematically searched international datasets to identify relevant studies. Finally, 33 studies were included in the review. Our review discusses the effects of RF-EMFs on the amyloid β (Aβ), oxidative stress, apoptosis, reactive oxygen species (ROS), neuronal death, and astrocyte responses. Moreover, the role of exposure parameters, including the type of exposure, its duration, and specific absorption rate (SAR), are discussed. Results: Progressive factors of AD such as Aβ, myelin basic protein (MBP), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and neurofilament light polypeptide (NFL) were decreased. While tau protein showed no change, factors affecting brain activity such as glial fibrillary acidic protein (GFAP), mitogen-activated protein kinases (MAPKs), cerebral blood flow (CBF), brain temperature, and neuronal activity were increased. Conclusion: Exposure to low levels of RF-EMFs can reduce the risk of AD by increasing MAPK and GFAP and decreasing MBP. Considering the role of apoptosis in AD and the effect of RF-EMF on the progression of the process, this review indicates the positive effect of these exposures.

Indexed as

Alzheimer’s DiseaseCellphoneDementiaNeurodegenerative DiseasesNon-Ionizing Radiation

Identifiers

PMID36818013
PMCPMC9923247
OpenAlexW4318485737

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.