ArticleCritical care explorations2023
Timing of Intubation in COVID-19: When It Is Too Early and When It Is Too Late.
Article in Critical care explorations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Prediction of high-flow nasal cannula failure in patients with sepsis by a preliminary risk stratification model based on the ROX index.BMC infectious diseases · 2026Article
- Delayed intubation and 60-day mortality in severe COVID-19-associated acute respiratory failure in an emulated target trial using the OUTCOMEREA network.Scientific reports · 2026Article
- Intubated COVID-19 Patients More Likely to Develop Subglottic Stenosis.Laryngoscope investigative otolaryngology · 2026Article
- Factors associated with the intubation of patients with acute respiratory failure and their impact on mortality: a retrospective cohort study.BMC pulmonary medicine · 2025Article
- Impact of low dose inhaled nitric oxide treatment in spontaneously breathing and intubated COVID-19 patients: a retrospective propensity-matched study.Critical care (London, England) · 2024Article
- Neutrophil-to-Lymphocyte Ratio and Cytokine Profiling as Predictors of Disease Severity and Survival in Unvaccinated COVID-19 Patients.Vaccines · 2024Article
- Effect of noninvasive ventilation on mortality and clinical outcomes among patients with severe hypoxemic COVID-19 pneumonia after high-flow nasal oxygen failure: a multicenter retrospective French cohort with propensity score analysis.Respiratory research · 2024Article
- The Respiratory Mechanics of COVID-19 Acute Respiratory Distress Syndrome-Lessons Learned?Journal of clinical medicine · 2024Review
- Article
- Analysis of an Individualised Stepwise Approach to Non-Pharmacological Therapy in COVID-19.Respiration; international review of thoracic diseases · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The timing of initiating mechanical ventilation in patients with acute respiratory distress syndrome due to COVID-19 remains controversial. At the outset of the pandemic, "very early" intubation was recommended in patients requiring oxygen flows above 6 L per minute but was followed closely thereafter by avoidance of invasive mechanical ventilation (IMV) due to a perceived (yet over-estimated) risk of mortality after intubation. While the use of noninvasive methods of oxygen delivery, such as high-flow nasal oxygen (HFNO) or noninvasive positive pressure ventilation (NIV), can avert the need for mechanical ventilation in some, accumulating evidence suggests delayed intubation is also associated with an increased mortality in a subset of COVID-19 patients. Close monitoring is necessary in COVID-19 patients on HFNO or NIV to identify signs of noninvasive failure and ensure appropriate provision of IMV.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.