Evidence map›Paper›PMID 36817957›Full record

ArticleComputational and structural biotechnology journal2023

The glycine

Stefan Kühn, Monray E Williams, Marli Dercksen, Jörn Oliver Sass, Rencia van der Sluis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. GlycineJIMD reports · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Stefan KühnFocus Area for Human Metabolomics, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa.
Monray E WilliamsFocus Area for Human Metabolomics, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa.
Marli DercksenFocus Area for Human Metabolomics, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa.
Jörn Oliver SassResearch Group Inborn Errors of Metabolism, Institute for Functional Gene Analytics, Department of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, von-Liebig-Str. 20, 53359 Rheinbach, Germany.
Rencia van der SluisFocus Area for Human Metabolomics, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa.
North-West University · ZAHochschule Bonn-Rhein-Sieg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Isovaleric acidemia (IVA), due to isovaleryl-CoA dehydrogenase (IVD) deficiency, results in the accumulation of isovaleryl-CoA, isovaleric acid and secondary metabolites. The increase in these metabolites decreases mitochondrial energy production and increases oxidative stress. This contributes to the neuropathological features of IVA. A general assumption in the literature exists that glycine

Indexed as

Glycine conjugationGlycine N-acyltransferaseIsovaleric acidemiaN-isovalerylglycine

Identifiers

PMID36817957
PMCPMC9932296
OpenAlexW4318566937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.