ArticleFrontiers in public health2023
Triglyceride glucose-body mass index and the risk of progression to diabetes from prediabetes: A 5-year cohort study in Chinese adults.
Article in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metabolic syndrome components individually worsen the outcome of acute pancreatitis: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Association of cumulative exposure and change patterns of triglyceride-glucose index combined with novel obesity indices with glycemic transitions in prediabetes: evidence from the China Health and Retirement Longitudinal Study (CHARLS).Cardiovascular diabetology · 2026Observational
- Correlation analysis of serum glycosylphosphatidylinositol mannosyltransferase 1 (GMP1) levels in type 2 diabetes mellitus patients.Journal of medical biochemistry · 2026Article
- Association between triglyceride glucose-body mass index and incident risk of heart failure among patients with type 2 diabetes: a real-world study.Frontiers in endocrinology · 2026Observational
- Article
- METS-IR predicts new-onset stroke in older adults with stages 0-3 cardiovascular-kidney-metabolic syndrome: a prospective, multicohort, clinical study with statistical and machine learning.Diabetology & metabolic syndrome · 2025Article
- Observational
- Relationship Between Insulin Resistance Indicators and Type 2 Diabetes Mellitus in Romania.International journal of molecular sciences · 2025Article
- Predictive value of MetS-IR for the glucose status conversion in prediabetes: a multi-center retrospective cohort study.BMC endocrine disorders · 2025Article
- Sex differences in associations of metabolic inflammation and insulin resistance with incident type 2 diabetes mellitus: a retrospective cohort of adults with annual health examinations.Lipids in health and disease · 2025Article
- Triglyceride-glucose index in predicting the risk of new-onset diabetes in the general population aged 45 years and older: a national prospective cohort study.BMC endocrine disorders · 2025Article
- Nonlinear association between gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio and risk of progression from normoglycemia to prediabetes: a 5-year cohort study.Frontiers in endocrinology · 2025Article
- Sex differences in the association between atherogenic index of plasma and progression from normoglycemia to prediabetes: evidence from a 5-year large-scale retrospective cohort study.Frontiers in endocrinology · 2025Observational
- Stronger associations of abdominal obesity-related triglyceride-glucose indices with type 2 diabetes compared to general obesity-related indices in community-dwelling Chinese adults: a cross-sectional study.Frontiers in endocrinology · 2025Article
- Association between all-cause mortality and triglyceride glucose body mass index among critically ill patients with sepsis: a retrospective cohort investigation.Lipids in health and disease · 2024Article
- Article
- A longitudinal study on the impact of the TyG Index and TG/HDL-C ratio on the risk of type 2 diabetes in Chinese patients with prediabetes.Lipids in health and disease · 2024Article
- Association of caffeine intake with all-cause and cardiovascular mortality in diabetes and prediabetes.Diabetology & metabolic syndrome · 2024Article
- Non-insulin-based insulin resistance indices predict early neurological deterioration in elderly and middle-aged acute ischemic stroke patients in Northeast China.Scientific reports · 2024Article
- Association between surrogate marker of insulin resistance and bone mineral density in US adults without diabetes.Archives of osteoporosis · 2024Article
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Abstract
Objective: Evidence regarding the relationship between the triglyceride glucose-body mass index (TyG-BMI) and the risk of progression from prediabetes to diabetes remains limited. Our study aimed to investigate the relationship between them in patients with prediabetes. Methods: In this retrospective cohort study, data were collected from 25,279 patients with prediabetes who received health checks between 2010 and 2016. We used a Cox proportional-hazards regression model to examine the relationship between TyG-BMI and diabetes risk. We used Cox proportional hazards regression with cubic spline functions and smooth curve fitting to identify the nonlinear relationship between them. In addition, A series of sensitivity and subgroup analyses were also conducted. Results: The mean age of the included participants was 49.29 ± 13.82 years old, and 1,6734 (66.2%) were male. The mean TyG-BMI was 219.47. The median follow-up time was 2.89 years, and 2,687 (10.63%) individuals had a final diagnosis of diabetes. After adjusting for covariates, TyG-BMI was positively linked with incident diabetes in patients with prediabetes (HR = 1.011, 95%CI 1.010-1.012). TyG-BMI had a non-linear connection with diabetes risk, and its inflection point was 231.66. Right and left effects sizes (HR) at the inflection point were 1.017 (95%CI:1.014-1.019) and 1.007 (95%CI:1.005-1.009), respectively. The sensitivity analysis demonstrated the robustness of these results. Conclusion: This study demonstrated a positive, non-linear relationship between the TyG-BMI and diabetes risk in Chinese patients with prediabetes. When the TyG-BMI was <231.66, there was a significant positive association between TyG-BMI and the risk of progression from prediabetes to diabetes. This study serves as a reference to promote clinical consultation and optimize diabetes prevention decisions for patients with prediabetes.
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