Evidence map›Paper›PMID 36817722›Full record

ArticleAdvanced engineering materials2023

Anti-Biofilm Activity of a Tunable Hypochlorous Acid-Generating Electrochemical Bandage Controlled By a Wearable Potentiostat.

Abdelrhman Mohamed, Yash S Raval, Suzanne Gelston, Gretchen Tibbits, Suat U Ay, Laure Flurin, Kerryl E Greenwood-Quaintance, Robin Patel, Haluk Beyenal

Open access · hybridAbstract read
In one paragraph

Article in Advanced engineering materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Evaluation of treatment of methicillin-resistantAntimicrobial agents and chemotherapy · 2024
    Article
  7. Evaluation of Treatment of Methicillin-ResistantbioRxiv : the preprint server for biology · 2024
    Article
  8. HOCl-producing electrochemical bandage for treatingAntimicrobial agents and chemotherapy · 2024
    Article
  9. Article
  10. Antimicrobial agents and chemotherapy · 2023
    Article
  11. HWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Abdelrhman MohamedThe Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Pullman, WA, USA.
Yash S RavalDivision of Clinical Microbiology, Mayo Clinic, Rochester, MN, USA.
Suzanne GelstonThe Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Pullman, WA, USA.
Gretchen TibbitsThe Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Pullman, WA, USA.
Suat U AyDepartment of Electrical and Computer Engineering, University of Idaho, Moscow.
Laure FlurinDivision of Clinical Microbiology, Mayo Clinic, Rochester, MN, USA.
Kerryl E Greenwood-QuaintanceDivision of Clinical Microbiology, Mayo Clinic, Rochester, MN, USA.
Robin PatelDivision of Clinical Microbiology, Mayo Clinic, Rochester, MN, USA.
Haluk BeyenalThe Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Pullman, WA, USA.
Mayo Clinic · USWashington State University · USUniversity of Idaho · US

Funding

The Electricidal Effect, a Novel Anti-Biofilm StrategyR01AI091594 · NIAID · MAYO CLINIC ROCHESTER · PI Haluk Beyenal, Robin Patel · 2011 to 2026
$5.5M
NIAID NIH HHS R01 AI091594
6 · The paper itself

Abstract

Chronic wound biofilm infections represent a major clinical challenge which results in a substantial burden to patients and healthcare systems. Treatment with topical antibiotics is oftentimes ineffective as a result of antibiotic-resistant microorganisms and biofilm-specific antibiotic tolerance. Use of biocides such as hypochlorous acid (HOCl) has gained increasing attention due to the lack of known resistance mechanisms. We designed an HOCl-generating electrochemical bandage (e-bandage) that delivers HOCl continuously at low concentrations targeting infected wound beds in a similar manner to adhesive antimicrobial wound dressings. We developed a battery-operated wearable potentiostat that controls the e-bandage electrodes at potentials suitable for HOCl generation. We demonstrated that e-bandage treatment was tunable by changing the applied potential. HOCl generation on electrode surfaces was verified using microelectrodes. The developed e-bandage showed time-dependent responses against

Indexed as

biofilme-bandageelectrochemical bandagehypochlorous acidwearable potentiostatwoundwound healing

Identifiers

PMID36817722
PMCPMC9937732
OpenAlexW4307575406

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.