Evidence map›Paper›PMID 36817600›Full record

ArticleFrontiers in endocrinology2023

Effect of maternal periconceptional undernutrition in sheep on cortisol regulation in offspring from mid-late gestation, through to adulthood.

Mark H Oliver, Anne L Jaquiery, Kristin L Connor, Hui Hui Phua, Jane E Harding, Eric B Thorstensen, Frank H Bloomfield

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Mark H OliverLiggins Institute, University of Auckland, Auckland, New Zealand.
Anne L JaquieryLiggins Institute, University of Auckland, Auckland, New Zealand.
Kristin L ConnorDepartment of Health Sciences, Carleton University, Ottawa, ON, Canada.
Hui Hui PhuaLiggins Institute, University of Auckland, Auckland, New Zealand.
Jane E HardingLiggins Institute, University of Auckland, Auckland, New Zealand.
Eric B ThorstensenLiggins Institute, University of Auckland, Auckland, New Zealand.
Frank H BloomfieldLiggins Institute, University of Auckland, Auckland, New Zealand.
University of Auckland · NZCarleton University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Maternal periconceptional undernutrition (PCUN) alters fetal hypothalamic-pituitary-adrenal axis (HPAA) function and placental glucocorticoid metabolism in sheep. The effects of PCUN on HPAA function in adult life are not known. We investigated the effects of PCUN on fetal adrenal development across gestation and on cortisol regulation in adult offspring. Methods: Ewes were undernourished from 61 days before to 30 days after conception ('PCUN') or fed Results: Fetal adrenal Conclusions: We conclude that the effects of PCUN on fetal HPAA function that became apparent in late gestation, are not reflected in adrenal cortisol secretion in mid-adulthood.

Indexed as

HydrocortisoneMalnutritionAdrenocorticotropic HormoneAnimalsCorticotropin-Releasing HormoneFemaleHypothalamo-Hypophyseal SystemMaleMaternal-Fetal ExchangeMetyraponePituitary-Adrenal SystemPlacentaPregnancyReceptors, GlucocorticoidRNA, MessengerSheepAdrenocorticotropic HormoneCorticotropin-Releasing HormoneHydrocortisoneMetyraponeReceptors, GlucocorticoidRNA, Messengeradrenalcortisollong-termoutcomesprogramming

Identifiers

PMID36817600
PMCPMC9932192
OpenAlexW4319036420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.