Evidence map›Paper›PMID 36817487›Full record

ArticleFrontiers in immunology2023

IL-17A expression by both T cells and non-T cells contribute to HSV-IL-2-induced CNS demyelination.

Satoshi Hirose, Shaohui Wang, Ujjaldeep Jaggi, Harry H Matundan, Mihoko Kato, Xue-Ying Song, Sara J Molesworth-Kenyon, Robert N Lausch, Homayon Ghiasi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Satoshi HiroseCenter for Neurobiology & Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Shaohui WangCenter for Neurobiology & Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Ujjaldeep JaggiCenter for Neurobiology & Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Harry H MatundanCenter for Neurobiology & Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Mihoko KatoDepartment of Biology, Pomona College, Claremont, CA, United States.
Xue-Ying SongApplied Genomics, Computation, and Translational Core, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Sara J Molesworth-KenyonDepartment of Natural Sciences, University of West Georgia, Carrollton, GA, United States.
Robert N LauschDepartment of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, Al, United States.
Homayon GhiasiCenter for Neurobiology & Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Cedars-Sinai Medical Center · USPomona College · USUniversity of South Alabama · USUniversity of West Georgia · US

Funding

The Role of gK in HSV-1 Induced Corneal ScarringR01EY013615 · NEI · CEDARS-SINAI MEDICAL CENTER · PI HOMAYON GHIASI · 2002 to 2026
$7.8M
Therapeutic control of HSK by CD80R01EY026944 · NEI · CEDARS-SINAI MEDICAL CENTER · PI GHIASI, HOMAYON · 2016 to 2025
$3.9M
Role of type 2 Innate Lymphoid Cells (ILC2s) in optic neuritisR01EY029677 · NEI · CEDARS-SINAI MEDICAL CENTER · PI GHIASI, HOMAYON · 2019 to 2022
$1.8M
NEI NIH HHS R01 EY013615NEI NIH HHS R01 EY026944NEI NIH HHS R01 EY029677
6 · The paper itself

Abstract

Previously we reported that a recombinant HSV-1 expressing murine IL-2 (HSV-IL-2) causes CNS demyelination in different strains of mice and in a T cell-dependent manner. Since T

Indexed as

Demyelinating DiseasesT-LymphocytesAnimalsBrainHerpesvirus 2, HumanInterleukin-17Interleukin-2MiceInterleukin-17Interleukin-2HSV-IL-2IL17RAIL17RCIL17RDknockoutmouseOcular infection

Identifiers

PMID36817487
PMCPMC9931899
OpenAlexW4319039627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.