Evidence map›Paper›PMID 36817228›Full record

ArticleJournal of translational genetics and genomics2023

Epigenetic effects of high-fat diet on intestinal tumorigenesis in C57BL/6J-

Dan C Qu, Devin Neu, Zain Q Khawaja, Ruoyu Wang, Cynthia F Bartels, Katreya Lovrenert, Ernest R Chan, Anne E Hill-Baskin, Peter C Scacheri, Nathan A Berger

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational genetics and genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Loss ofTheranostics · 2025
    Article
  2. Review
  3. Obesity associated cancers, genetics, epigenetics and elephants.Journal of translational genetics and genomics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Dan C QuCenter for Science, Health and Society, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Devin NeuDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Zain Q KhawajaCenter for Science, Health and Society, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Ruoyu WangCenter for Science, Health and Society, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Cynthia F BartelsDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Katreya LovrenertDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Ernest R ChanCleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA.
Anne E Hill-BaskinCenter for Science, Health and Society, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Peter C ScacheriDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Nathan A BergerCenter for Science, Health and Society, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Case Western Reserve University · USUniversity School · US

Funding

TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Amar Desai · 1987 to 2026
$142.3M
Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5M
Targeting 15-PGDH in Colon Cancer Prognosis, Prediction, Treatment and PreventionP50CA150964 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARKOWITZ, SANFORD D. · 2011 to 2022
$24.6M
Case CCC Youth Engaged in Science, 09/01/2022-08/31/2027R25CA221718 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Jason Mears · 2017 to 2026
$4.4M
The role of gene enhancer elements in colon cancerR01CA160356 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI TESAR, PAUL JOSEPH · 2012 to 2023
$3.6M
Role of enhancer elements in regulating prometastatic transcriptional programs in osteosarcomaR01CA193677 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI SCACHERI, PETER CHRISTOPHER · 2016 to 2020
$1.8M
NCATS NIH HHS UL1 TR002548NCI NIH HHS P30 CA043703NCI NIH HHS P50 CA150964NCI NIH HHS R01 CA160356NCI NIH HHS R01 CA193677NCI NIH HHS R25 CA221718
6 · The paper itself

Abstract

Aim: Obesity and obesogenic diets might partly accelerate cancer development through epigenetic mechanisms. To determine these early effects, we investigated the impact of three days of a high-fat diet on epigenomic and transcriptomic changes in Method: ChIP-Seq and RNA-Seq were performed on small intestinal epithelia of WT and Results: Regarding epigenetic and transcriptomic changes, diet type (LFD Conclusion: Three days of HFD-induced epigenomic and transcriptomic changes involving metabolic and immunologic pathways that may promote tumor growth in the genetically predisposed murine intestine without affecting key cancer signaling pathways.

Indexed as

ApcMin/+epigenetic changeslipid metabolic processesObesogenic diet

Identifiers

PMID36817228
PMCPMC9937564
OpenAlexW4318594339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.