Novel Prognostic Biomarkers for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (CESC) Patients via Analysis of Competing Endogenous RNA (ceRNA) Network.

Yanru Dong, Weibo Wen, Tiezheng Yuan, Lan Liu, Xiangdan Li

RetractedAbstract readRetracted Publication

In one paragraph

Article in Disease markers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

4 · The record

Corrections and comments

Retraction · 2023-07-26Concerns/Issues about Data · Concerns/Issues about Results and/or Conclusions · Concerns/Issues about Referencing/Attributions · Concerns/Issues about Peer Review · Informed/Patient Consent - None/Withdrawn · Investigation by Journal/Publisher · Investigation by Third Party · Lack of IRB/IACUC Approval and/or Compliance · Computer-Aided Content or Computer-Generated Content · Unreliable Results and/or Conclusions · · See also: https://pubpeer.com/publications/DC8A96C7F25EC78E40CA98DDC2C448
Retracted
Retracted: Novel Prognostic Biomarkers for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (CESC) Patients via Analysis of Competing Endogenous RNA (ceRNA) Network.2023

5 · Who and what money

Authors and funding

5 authors.

Yanru DongDepartment of Morphological Experiment Center, Medical College of Yanbian University, Yanji City, 133000 Jilin, China.

Weibo WenDepartment of Morphological Experiment Center, Medical College of Yanbian University, Yanji City, 133000 Jilin, China.

Tiezheng YuanDepartment of Morphological Experiment Center, Medical College of Yanbian University, Yanji City, 133000 Jilin, China.

Lan LiuDepartment of Pathology, Affiliated Hospital of Yanbian University, Yanji City, 133000 Jilin, China.ORCID https://orcid.org/0000-0002-3566-9666

Xiangdan LiDepartment of Morphological Experiment Center, Medical College of Yanbian University, Yanji City, 133000 Jilin, China.ORCID https://orcid.org/0000-0002-3002-5482

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) is a common malignant gynecological cancer. The ceRNA networks play important roles in many tumors, while RILPL2-related ceRNA network has been seldom studied in CESC. Methods: All CESC data was obtained from TCGA database. Differentially expressed RNAs and predicted target RNAs were cross analyzed to construct ceRNA network. RNA and clinicopathological characteristics' influence on overall survival (OS) were determined by univariate and multivariate Cox regression analyses. Lasso regression was used to construct the prediction model. Coexpression analysis was performed to explore the association of gene expression with CESC. This was followed by an experimental validation based on these results. Results: Between high and low RILPL2 expression CESC patients, totally 1227 DEmRNAs, 39 DEmiRNAs, and 1544 DElncRNAs were identified. After multiple cross analyses, 1 miRNA hsa-miR-1293, 20 mRNAs, and 43 lncRNAs were maintained to construct ceRNA network. CADM3-AS1, LINC00092, and ZNF667-AS1 in ceRNA network were significantly associated with the OS of CESC patients, and patients with low expression of these lncRNAs had worse prognosis. Significant lower expressions of these lncRNAs were also observed in CESC cell line compared with normal cell line. Conclusion: Low expressions of CADM3-AS1, LINC00092, and ZNF667-AS1 in ceRNA network were probably promising poor prognostic biomarkers for CESC patients. The genes show a prospective research area for CESC-targeted treatment in the future.

Indexed as

AdenocarcinomaCarcinoma, Squamous CellMicroRNAsRNA, Long NoncodingUterine Cervical NeoplasmsBiomarkersBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansKaplan-Meier EstimatePrognosisProspective StudiesBiomarkersBiomarkers, TumorMicroRNAsMIRN1293 microRNA, humanRNA, Long Noncoding

Identifiers

PMID36817087

DOI10.1155/2023/1766080

PMCPMC9936453

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.