Evidence map›Paper›PMID 36816882›Full record

ArticlePhotoacoustics2023

Photoacoustic/ultrasonic dual-mode imaging for monitoring angiogenesis and synovial erosion in rheumatoid arthritis.

Zhen Wang, Zhuangzhuang Tong, Hongjiang Chen, Guangshuai Nie, Jia Hu, Weiyang Liu, Erqi Wang, Bo Yuan, Zhiyang Wang, Jun Hu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photoacoustics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Zhen WangDepartment of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, PR China.
Zhuangzhuang TongMOE Key Laboratory of Laser Life Science & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, PR China.
Hongjiang ChenDepartment of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, PR China.
Guangshuai NieDepartment of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, PR China.
Jia HuDepartment of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, PR China.
Weiyang LiuDepartment of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, PR China.
Erqi WangMOE Key Laboratory of Laser Life Science & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, PR China.
Bo YuanMOE Key Laboratory of Laser Life Science & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, PR China.
Zhiyang WangMOE Key Laboratory of Laser Life Science & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, PR China.
Jun HuDepartment of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, PR China.
South China Normal University · CNShantou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the formation of new vessels, synovial proliferation and destruction of articular cartilage. However, characteristic early diagnostic and therapeutic monitoring methods are still lacking. We report a study using a photoacoustic/ultrasound (PA/US) dual-mode imaging for RA disease. By establishing a collagen-induced (CIA) RA mouse model to classify disease states based on a subjective grading system, PA/US imaging allows real-time assessment of synovial erosion and vascular opacification within the knee joint in different disease states at high spatial resolution. The system also quantitatively monitors subcutaneous vascular physiology and morphology in the hind paw of mice, measuring the area and photoacoustic signal intensity of vascular proliferation and showing a positive correlation with disease grading. Compared to traditional subjective scoring of arthritis severity, the PA/US imaging is more sensitive i.e., vascular signals and synovial erosion can be observed early in the course of arthritis.

Indexed as

AngiogenesisPhotoacoustic imagingRheumatoid arthritisUltrasonic imaging

Identifiers

PMID36816882
PMCPMC9929594
OpenAlexW4319304124

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.