Evidence map›Paper›PMID 36816838›Full record

ArticleAdvanced functional materials2023

A Dual-network Nerve Adhesive with Enhanced Adhesion Strength Promotes Transected Peripheral Nerve Repair.

Wen Xue, Wen Shi, Mitchell Kuss, Yunfan Kong, Olawale A Alimi, Hanjun Wang, Dominick J DiMaio, Cunjiang Yu, Bin Duan

Open access · bronzeAbstract read
In one paragraph

Article in Advanced functional materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 59 citations in OpenAlex.

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  6. Catechol Derivative-Based Bioadhesives: Molecular Design for Precision Medical Adhesion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Wen XueDepartment of Internal Medicine, Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
Wen ShiDepartment of Internal Medicine, Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
Mitchell KussDepartment of Internal Medicine, Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
Yunfan KongDepartment of Internal Medicine, Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
Olawale A AlimiDepartment of Internal Medicine, Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
Hanjun WangDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
Dominick J DiMaioDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.
Cunjiang YuDepartment of Biomedical Engineering, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Bin DuanDepartment of Internal Medicine, Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.ORCID 0000-0002-5647-3793
Nebraska Medical Center · USPennsylvania State University · USUniversity of Nebraska–Lincoln · US

Funding

A Hydrogel Ionic Circuit-Based Electrical Stimulation System for Restoration of Denervated Muscles After Peripheral Nerve InjuriesR21AR078439 · NIAMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DUAN, BIN, ZHAO, SIWEI · 2021 to 2022
$378k
NIAMS NIH HHS R21 AR078439
6 · The paper itself

Abstract

Peripheral nerve transection has a high prevalence and results in functional loss of affected limbs. The current clinical treatment using suture anastomosis significantly limits nerve recovery due to severe inflammation, secondary damage, and fibrosis. Fibrin glue, a commercial nerve adhesive as an alternative, avoids secondary damage but suffers from poor adhesion strength. To address their limitations, a highly efficacious nerve adhesive based on dual-crosslinking of dopamine-isothiocyanate modified hyaluronic acid and decellularized nerve matrix is reported in this paper. This dual-network nerve adhesive (DNNA) shows controllable gelation behaviors feasible for surgical applications, robust adhesion strength, and promoted axonal outgrowth

Indexed as

bioadhesivecatecholdecellularized matrixnerve regeneration

Identifiers

PMID36816838
PMCPMC9937437
OpenAlexW4308393568

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.