ArticleFrontiers in aging neuroscience2022
Evolution characteristics of dynamic balance disorder over the course of PD and relationship with dopamine depletion.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Machine learning classification of early-stage Parkinson's disease using sit-to-walk biomechanical features.Scientific reports · 2026Article
- Utility of gait biomarkers in screening for obstructive sleep apnea among patients with Parkinson's disease: a cross-sectional study.BMC neurology · 2026Article
- The efficacy and safety of high-frequency SMA-rTMS on freezing of gait in patients with Parkinson's disease: a study protocol for a randomized controlled trial.BMC complementary medicine and therapies · 2026Article
- Higher Serum Aspartate May be Associated with Better Cognitive Function as Mediated by Reduced Aβ Accumulation in Frontal and Temporal Lobes in Mild Cognitive Impairment.Journal of molecular neuroscience : MN · 2025Article
- Do the gait domains change in PD patients with freezing of gait during their 'interictal' period?BMC geriatrics · 2025Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to assess the evolution of dynamic balance impairment during the course of Parkinson's disease (PD) and to clarify the contribution of striatal dopaminergic innervation to poor dynamic balance. Methods: In our study, 89 patients with PD (divided into 2 groups according to the H-Y stage) and 39 controls were included. Kinematic data were recorded by a portable inertial measurement unit system. Dopaminergic loss in the striatal subregion was verified through the Results: Patients with early PD presented with imbalance featured by smaller three-dimensional trunk ROM with reduced trunk coronal angular velocity during walking and with reduced trunk sagittal angular velocity during the stand-to-sit task (all Conclusion: The dynamic balance in PD was impaired from the early stages, and the characteristics of the impairment changed differently as the disease progressed. Dopaminergic denervation has a lower contribution to dynamic balance disorders throughout PD.
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