Evidence map›Paper›PMID 36816714›Full record

ArticleInternational journal of hepatology2023

Gamma-Glutamyl Transferase: A Friend against Cholestatic Itch? A Retrospective Observational Data Analysis in Patients with Extrahepatic Cholestasis.

Floris W Haijer, Cornelis B Van Vliet, Marjolein G J Brusse-Keizer, Job A M Van der Palen, Marjo J Kerbert-Dreteler, Jeroen J Kolkman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of hepatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Floris W HaijerDepartment of Gastroenterology and Hepatology, Medical Spectre Twente, Netherlands.ORCID https://orcid.org/0000-0002-2641-5170
Cornelis B Van VlietDepartment of Gastroenterology and Hepatology, Medical Spectre Twente, Netherlands.
Marjolein G J Brusse-KeizerDepartment of Statistics, Medical Spectre Twente, Netherlands.ORCID https://orcid.org/0000-0003-1781-5794
Job A M Van der PalenDepartment of Statistics, Medical Spectre Twente, Netherlands.
Marjo J Kerbert-DretelerDepartment of Gastroenterology and Hepatology, Medical Spectre Twente, Netherlands.
Jeroen J KolkmanDepartment of Gastroenterology and Hepatology, Medical Spectre Twente, Netherlands.ORCID https://orcid.org/0000-0002-0442-827X
Medisch Spectrum Twente · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methods: We included 235 patients with chronic extrahepatic cholestasis due to pancreatic cancer, cholangiocarcinoma, or papillary carcinoma. Results: GGT was significantly higher in patients without pruritus (median 967, IQR 587-1571) compared to patients with pruritus (median 561 IQR 266-1084 IU/l) ( Conclusion: Serum GGT activity is inversely associated with the presence of cholestatic itch in patients with chronic extrahepatic cholestasis.

Identifiers

PMID36816714
PMCPMC9931488
OpenAlexW4319593331

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.