ArticleFrontiers in cellular and infection microbiology2023
Short-term effects of Chlorhexidine mouthwash and Listerine on oral microbiome in hospitalized patients.
Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Ozonated water as a preventive oral hygiene aid: a systematic review and meta-analysis of its role in reducing dental plaque.Evidence-based dentistry · 2026Pooled it
- Development of oral dysbiosis following use of antimicrobial mouthwashes: a systematic review.Odontology · 2026Pooled it
- Clinical efficacy and patient-reported outcomes of coconut oil as adjunctive periodontitis treatment: triple-blinded pilot randomized trial.BMC oral health · 2026Trial
- Effect of periodontal therapy on lung function: a twelve-month follow-up intervention study.Respiratory research · 2025Trial
- Oral Hygiene With Neutral Electrolyzed Water and Systemic Therapy Increases Gastric Helicobacter pylori Eradication and Reduces Recurrence.Clinical and experimental dental research · 2024Trial
- Use of over-the-counter mouthwashes as an additional measure in individual oral prophylaxis on adults with plaque-induced gingivitis: a double-blind, parallel, randomized controlled trial.BMC oral health · 2024Trial
- Control of Dental Plaque and Gingival Inflammation by Natural Ingredients-Based Mouthwash.Dentistry journal · 2025Article
- Nanostructured Clays Used as Carriers for Controlled Delivery of Antibacterial Compounds From Direct Restorative Dental Materials: A Scoping Review.Clinical and experimental dental research · 2025Article
- Oral Microbiome Changes During Hospitalization in Older Adults Not Receiving Mechanical Ventilation.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2025Observational
- Application of sugar-free cola solution based on the ICOCFAS score in oral care of non-artificial airway patients with severe neurological conditions.Frontiers in medicine · 2025Article
- The Effect of Coconut and Frankincense Oils on the Biofilm Growth ofF1000Research · 2025Article
- Role of oral and gut microbiomes in enterosalivary nitrate metabolism and their effects on systemic disease.Frontiers in cellular and infection microbiology · 2025Review
- Natural Antimicrobial Peptides and Their Synthetic Analogues for Effective Oral Microflora Control and Oral Infection Treatment-The Role of Ceragenins in the Development of New Therapeutic Methods.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Efficacy of Ceragenins in Controlling the Growth of Oral Microorganisms: Implications for Oral Hygiene Management.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Antiseptics: An expeditious third force in the prevention and management of coronavirus diseases.Current research in microbial sciences · 2024Review
- The effects of nitrate on the oral microbiome: a systematic review investigating prebiotic potential.Journal of oral microbiology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Chlorhexidine (CHX) and essential oil containing mouthwashes like Listerine Methods: We recruited 87 hospitalized patients from a previous randomized control study, and assigned them to three mouthwash groups: CHX, Listerine, and normal saline (control). Before and after gargling the mouthwash twice a day for 5-7 days, oral bacteria were examined using a 16S rDNA approach. Results: Alpha diversities at the genus level decreased significantly only for the CHX and Listerine groups. Only for the two groups, oral microbiota before and after gargling were significantly different, but not clearly distinct. Paired analysis eliminated the substantial individual differences and revealed eight bacterial genera (including Discussion: In conclusion, short-term gargling of the CHX mouthwash and Listerine altered oral microbiota in our hospitalized patients. The bacterial genera targeted by the CHX mouthwash and Listerine were largely different and the magnitudes of changes were smaller using Listerine. Functional alterations of gargling CHX and Listerine were also different. These findings can be considered for managing oral hygiene of hospitalized patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.