ArticlePediatric gastroenterology, hepatology & nutrition2023
Treatment of Symptomatic Focal Hepatic Hemangioma with Propranolol in Neonates: Is It Efficient?
Article in Pediatric gastroenterology, hepatology & nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 7 citations in OpenAlex.
- Evaluation of hepatic infantile hemangiomas: the potential of contrast-enhanced ultrasound.Frontiers in cardiovascular medicine · 2026Article
- Clinical characteristics and managements of congenital hepatic hemangioma: a cohort study of 211 cases.Hepatology international · 2025Observational
- Management of Neonatal Hepatic Hemangiomas: A Single-Center Experience Focused on Challenging Cases.Journal of clinical medicine · 2024Article
- Hepatic hemangiomas with arterioportal shunt complicated a congestive heart failure: a case report.The Pan African medical journal · 2023Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
Hepatic hemangiomas (HH) - classified into congenital hepatic hemangiomas (CHH) or infantile hepatic hemangiomas (IHH) - are benign vascular tumors that are mainly asymptomatic, but may cause clinical problems that require treatment. While focal, multifocal, and diffuse IHH are responsive to propranolol treatment, CHH is mainly focal and thought to be resistant to treatment with propranolol. The clinical and imaging distinctions between CHH and IHH in cases of focal lesions can be challenging, while histopathological distinction is mostly lacking in the clinical setting. We report 4 neonatal symptomatic cases of focal HH treated with propranolol, with partial or complete resolution of the tumor, and the positive hemodynamic effect of propranolol in one case. We believe that although clear differentiation cannot be achieved between CHH and IHH without histopathological examination in cases of focal HH in neonates, propranolol treatment should be attempted in symptomatic cases since its benefits outweigh the possible small risk of side effects of propranolol.
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