Evidence map›Paper›PMID 36816436›Full record

ArticlePediatric gastroenterology, hepatology & nutrition2023

Fecal Calprotectin and Cow's Milk-Related-Symptoms Score in Children with Cow's Milk Protein Allergy.

Sahar Zain-Alabedeen, Noha Kamel, Mona Amin, Angharad Vernon-Roberts, Andrew S Day, Abdelmoneim Khashana

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In one paragraph

Article in Pediatric gastroenterology, hepatology & nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Sahar Zain-AlabedeenDepartment of Pediatrics, Bilbeis Central Hospital, Zagazig, Egypt.ORCID https://orcid.org/0000-0002-0656-112X
Noha KamelDepartment of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.ORCID https://orcid.org/0000-0002-8990-2312
Mona AminDepartment of Pediatrics, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.ORCID https://orcid.org/0000-0002-8316-884X
Angharad Vernon-RobertsDepartment of Paediatrics, University of Otago Christchurch, Christchurch, New Zealand.ORCID https://orcid.org/0000-0001-9402-4959
Andrew S DayDepartment of Paediatrics, University of Otago Christchurch, Christchurch, New Zealand.ORCID https://orcid.org/0000-0003-2290-7386
Abdelmoneim KhashanaDepartment of Pediatrics, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.ORCID https://orcid.org/0000-0001-5365-1139
Suez Canal University · EGUniversity of Otago · NZZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The cow's milk-related-symptom-score (CoMiSS) tool was developed as an awareness tool for the assessment of cow's milk-related symptoms in infants or children. Fecal calprotectin (FC) is a noninvasive biomarker of gut inflammation that can be measured in serum and stool. This study aimed to investigate the relationship between FC levels and CoMiSS scores in infants with cow's milk protein allergy. Methods: Infants (aged 6-12 months) who were allergic to cow's milk protein were enrolled prospectively. Following completion of the CoMiSS scoring, the infants were divided into group 1 (positive CoMiSS scores ≥12) and group 2 (negative CoMiSS scores <12). FC was measured using immunoassay. Results: Of the 120 infants enrolled in this study, 60 (50.0%) had positive CoMiSS scores (group 1), while 60 (50.0%) had negative scores (group 2). The mean FC level was higher in the infants in group 1 than those in group 2 (2,934.57 µg/g vs. 955.13 µg/g; Conclusion: FC measurement may have a role in the assessing infants with CMPA.

Indexed as

CalprotectinCow milk protein allergyThe cow’s milk-related symptom score

Identifiers

PMID36816436
PMCPMC9911171
OpenAlexW4316039510

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.