Evidence map›Paper›PMID 36816428›Full record

ReviewGlomerular diseases

Super-Resolution Microscopy: A Technique to Revolutionize Research and Diagnosis of Glomerulopathies.

Florian Siegerist, Vedran Drenic, Thor-Magnus Koppe, Nihal Telli, Nicole Endlich

Open access · goldAbstract readReview
In one paragraph

Review in Glomerular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. The Life of a Kidney Podocyte.Acta physiologica (Oxford, England) · 2025
    Review
  5. Review
  6. Review
  7. Advances in Cellular and Molecular Biology Assays: A Review of Gold Standard Methods.International journal of innovative science and research technology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Florian SiegeristInstitute for Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.
Vedran DrenicNIPOKA GmbH, Greifswald, Germany.
Thor-Magnus KoppeInstitute for Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.
Nihal TelliNIPOKA GmbH, Greifswald, Germany.
Nicole EndlichInstitute for Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.
Universitätsmedizin Greifswald · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: For decades, knowledge about glomerular (patho)physiology has been tightly linked with advances in microscopic imaging technology. For example, the invention of electron microscopy was required to hypothesize about the mode of glomerular filtration barrier function. Summary: Super-resolution techniques, defined as fluorescence microscopy approaches that surpass the optical resolution limit of around 200 nm, have been made available to the scientific community. Several of these different techniques are currently in use in glomerular research. Using three-dimensional structured illumination microscopy, the exact morphology of the podocyte filtration slit can be morphometrically analyzed and quantitatively compared across samples originating from animal models or human biopsies. Key Messages: Several quantitative image analysis approaches and their potential influence on glomerular research and diagnostics are discussed. By improving not only optical resolution but also information content and turnaround time, super-resolution microscopy has the potential to expand the diagnosis of glomerular disease. Soon, these approaches could be introduced into glomerular disease diagnosis.

Indexed as

Fluorescence microscopyGlomerular diseaseQuantitative image analysisSuper-resolution microscopy

Identifiers

PMID36816428
PMCPMC9936760
OpenAlexW4313422590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.