Evidence map›Paper›PMID 36816171›Full record

ArticleJournal of community hospital internal medicine perspectives2022

POEMS Syndrome - A Diagnostic Dilemma with Challenging Presentation.

Mosunmoluwa Oyenuga, Mohamed M G Mohamed, Rushin Patel, Sara Sartaj, Sandeep Sen, Alexandre Lacasse, Vikas Kumar

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of community hospital internal medicine perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mosunmoluwa OyenugaDepartment of Internal Medicine, SSM Health St. Mary's Hospital-St. Louis, MO, USA.
Mohamed M G MohamedDepartment of Internal Medicine, SSM Health St. Mary's Hospital-St. Louis, MO, USA.
Rushin PatelDepartment of Internal Medicine, SSM Health St. Mary's Hospital-St. Louis, MO, USA.
Sara SartajDepartment of Internal Medicine, SSM Health St. Mary's Hospital-St. Louis, MO, USA.
Sandeep SenDivision of Hematology and Medical Oncology, SSM Health St. Mary's Hospital-St. Louis, MO, USA.
Alexandre LacasseDepartment of Internal Medicine, SSM Health St. Mary's Hospital-St. Louis, MO, USA.
Vikas KumarDivision of Neurology, SSM Health St. Mary's Hospital-St. Louis, MO, USA.
St. Mary's Hospital · USSt. Mary's Health Center · USSt. Mary's Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes (POEMS) syndrome is a rare disorder with multiple presentations and a constellation of symptoms. We present a 62 year-old female who presented to the Emergency Department for acute dyspnea. Chest Xray showed sclerotic lesions in the ribs and thoracic spine. Further imaging studies with computed tomography (CT) and positron emission tomography (PET) scans were suggestive of a benign process. Improvement was seen with supportive management. A few months later, patient developed neurological symptoms with reduced exercise tolerance. Mixed demyelinating and axonal polyneuropathy was diagnosed by electromyography. Further work up with bone marrow biopsy and immunochemistry testing revealed lambda and kappa plasma cell disorder, with elevated vascular endothelial growth factor (VEGF). Patient was diagnosed with POEMS and initiated on chemotherapy. POEMS syndrome is commonly missed due to its rarity and varied clinical presentations. VEGF plays a crucial role in the diagnosis. Management requires a multidisciplinary approach.

Indexed as

DemyelinatingEndocrinopathyM-proteinNeuropathyOrganomegalyPlasma cell disorderPOEMS syndromePolyneuropathySkin changes syndromeVascular endothelial growth factorVEGF

Identifiers

PMID36816171
PMCPMC9924649
OpenAlexW4308863801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.