Evidence map›Paper›PMID 36815858›Full record

Observational studyAntimicrobial agents and chemotherapy2023

Population Pharmacokinetics of Ganciclovir in Allogeneic Hematopoietic Stem Cell Transplant Patients.

Philip R Selby, Aaron J Heffernan, David Yeung, Morgyn S Warner, Sandra L Peake, Uwe Hahn, Steven C Wallis, Brett Mcwhinney, Jacobus P J Ungerer, Sepehr Shakib and 1 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Antimicrobial agents and chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Philip R SelbySchool of Medicine, University of Adelaide, Adelaide, Australia.ORCID 0000-0002-5647-4673
Aaron J HeffernanSchool of Medicine and Dentistry, Griffith University, Gold Coast, Queensland, Australia.ORCID 0000-0002-7929-9812
David YeungSchool of Medicine, University of Adelaide, Adelaide, Australia.
Morgyn S WarnerSchool of Medicine, University of Adelaide, Adelaide, Australia.
Sandra L PeakeSchool of Medicine, University of Adelaide, Adelaide, Australia.
Uwe HahnSchool of Medicine, University of Adelaide, Adelaide, Australia.
Steven C WallisUniversity of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Brett McwhinneyPathology Queensland, Queensland Health, Brisbane, Australia.
Jacobus P J UngererPathology Queensland, Queensland Health, Brisbane, Australia.
Sepehr ShakibSchool of Medicine, University of Adelaide, Adelaide, Australia.
Jason A RobertsUniversity of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0001-6218-435X
South Australia Pathology · AUQueensland Health · AURoyal Adelaide Hospital · AUThe University of Queensland · AUGriffith University · AUQueen Elizabeth Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment of cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell transplantation (alloHCT) patients with ganciclovir is complicated by toxicity and resistance. This study aimed to develop an intravenous ganciclovir population pharmacokinetic model for post-alloHCT patients and to determine dosing regimens likely to achieve suggested therapeutic exposure targets. We performed a prospective observational single-center pharmacokinetic study in adult alloHCT patients requiring treatment with intravenous ganciclovir for CMV viremia or disease. Samples were analyzed using a validated ultraperformance liquid chromatography method. Population pharmacokinetic analysis and Monte Carlo simulations (

Indexed as

Cytomegalovirus InfectionsHematopoietic Stem Cell TransplantationOrgan TransplantationAdultAntiviral AgentsGanciclovirHumansValganciclovirAntiviral AgentsGanciclovirValganciclovirallogeneic haematopoietic stem cell transplantationcytomegalovirusganciclovirpharmacokineticsvalganciclovir

Identifiers

PMID36815858
PMCPMC10019199
OpenAlexW4321613094

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.